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Test Name:
Thyrotropin Releasing Hormone


  • SBMF No:
    45699
  • Performance Lab Name:
    Inter Science Institute
  • Test Mnemonic:
    TRH-
  • ABN:
    Required – Not FDA-Approved
  • CPT Code:
    83519
  • LOINC Code:
    19146-0
  • Also Known As:
    TRH
  • Spec Type:
    Plasma
  • Spec Container:
    Special collection tube with TRH preservative
    Contact Client Services to order tube
    Tube should be stored in refrigerator prior to use
  • Pref Vol:
    2.0 mL
  • Min Vol:
    1.0 mL
  • Fasting:
    No
  • Patient Prep:
    Patient should not be on any thyroid medication, if possible, for at least 48 hours prior to collection of specimen
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Promptly centrifuge 15 minutes
    Immediately transfer plasma to separate plastic tube and freeze
  • Spec Store Transport:
    Frozen
  • Spec Remarks:
    Thyrotropin Releasing Hormone must be collected with the TRH Preservative. No other specimen is acceptable.
  • Methodology:
    Radioimmunoassay (RIA)
  • Clinical Significance:
    Thyrotropin Releasing Hormone (TRH) is a tripeptide produced primarily by the hypothalamus. TRH is produced from a prohormone which contains multiple copies of the TRH molecule meaning that several TRH entities can be released from one precursor. It has a stimulatory effect on the pituitary releasing Thyrotropin (TSH). TRH secretion is controlled in a negative feedback system by thyroid hormones. Binding of TRH to its receptor causes a rise in calcium which initiates TSH secretion. It also stimulates adenyl cyclase in the pituitary. TRH also stimulates secretion of Prolactin, Growth Hormone in Acromegaly, and ACTH in Cushing's and Nelson's Syndromes. Levels of TRH are non-detectable or very low in patients with Hyperthyroidism and Hypothalamic Hypothyroidism. Levels are elevated in patients with Primary and Pituitary Hypothyroidism.
  • Reference Range:

    Baseline Level:
    Up to 40 pg/ml

    Levels in Thyroid Dysfunction:
    Primary Hypothyroidism:
    40 - 400 pg/ml
    Pituitary Hypothyroidism:
    100 - 600 pg/ml
    Hypothalamic Hypothyroidism:
    Less than 5 pg/ml
    Hyperthyroidism:
    Less than 5 pg/ml

  • Additional Test Info:
    This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
  • Day Run:
    Varies
  • Time Reported:
    Varies
  • Test Type:
    HORMONE

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