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Test Name:
Thrombin-Antithrombin Complex
- SBMF No:
45683 - Performance Lab Name:
Quest Diagnostics Nichols Institute - Test Mnemonic:
TAT - ABN:
Not required - CPT Code:
83520 - LOINC Code:
19146-0 - Ref Lab Test No:
10162X - Also Known As:
TAT Complex - Spec Type:
Platelet-poor plasma (PPP) - Spec Container:
Light blue top (3.2% buffered sodium citrate) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
- Routine venipuncture
- • NOTE: Traumatic puncture invalidates sample for coagulation studies and necessitates recollection
• Observe proper collection order for coagulation tests; collect tubes for coagulation studies prior to collecting tubes containing clot activators, additives, or anticoagulants
• Fill light blue top tube to stated tube volume
• If coagulation study is only test ordered, collect 1.0 to 2.0 mL blood into tube for discard, then collect light blue top coagulation study tube(s)
• If multiple coagulation studies are requested, submit additional samples for each coagulation test
• Immediately after collection, gently invert tube to mix
- Spec Process:
- Separate plasma from cells immediately
- • Promptly centrifuge 15 minutes
• Carefully transfer plasma portion of sample to separate plastic tube using plastic pipette
• NOTE: Buffy coat layer of sample must be avoided
• Centrifuge transferred plasma sample again to produce platelet-poor plasma (PPP)
• Use second plastic pipette to carefully transfer PPP sample into plastic aliquot tubes
• Immediately freeze PPP samples
- Spec Store Transport:
Frozen - Spec Stability:
After separation from cells:
4 hours room temperature (20-30°C)
4 hours refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Non-frozen or thawed sample - Spec Remarks:
CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered - Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA) - Clinical Significance:
Thrombin-Antithrombin (TAT) Complex is a parameter of coagulation and fibrinolysis. The Thrombin-Antithrombin Complex keeps clotting in check. Deficiencies may aid in understanding hypercoagulable states. Elevated concentrations have been associated with vascular complications associated with diabetes. - Reference Range:
Less than 4 mcg/L - Day Run:
Sets up 1 day a week - Time Reported:
Reports in 4 days - Test Type:
COAGULATION
