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Test Name:
Immune Complex Panel
- SBMF No:
45557 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
C1Q/RAJI - ABN:
Not required - CPT Code:
86332x2 - LOINC Code:
27831-7; 10864-7 - Ref Lab Test No:
0050667 - Test Includes:
C1Q Binding Assay
Raji Cell Immune Complex Assay - Also Known As:
Circulating Immune Complex Panel - Also See:
44042 C1Q Binding Assay
44531 Raji Cell Immune Complex Assay - Spec Type:
Serum - Spec Container:
Red top (serum) tube(s) - Pref Vol:
Two 1.5 mL aliquots of serum - Min Vol:
Two 0.5 mL aliquots of serum - Fasting:
No - Spec Collect:
Do not use gel-barrier tubes for specimen collection
Routine venipuncture
Separate samples must be submitted when multiple tests are ordered - Spec Process:
Let stand on clot for 2 hours
Promptly centrifuge 15 minutes
Immediately transfer serum to two separate plastic tubes and freeze - Spec Store Transport:
Frozen - Spec Stability:
Refer to individual component tests - Spec Reject:
Non-frozen sample
Sample subjected to repeated freeze/thaw cycles - Spec Remarks:
CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered - Methodology:
Flow Cytometry
Enzyme-Linked Immunosorbent Assay - Clinical Significance:
Refer to:
- Reference Range:
- C1Q Binding Assay
- Less than 4 μgE/mL is considered negative for circulating complement binding immune complexes
- Interpretive Data:
- Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process.
- Raji Cell Immune Complex Assay
- By report
- Interpretive Data:
- Many autoimmune disorders, chronic infections and malignancies are associated with circulating immune complexes. Quantitation of immune complexes assists in staging immunologic disorders.
- Note:
- Immune complexes bind to Raji Cells via their complement receptors. The immunoglobulin portion of the immune complex is then detected by flow cytometry with anti-human IgG-FITC.
- Additional Test Info:
ASR Compliance Statement:
Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use. - Day Run:
Tue - Time Reported:
3-10 days - Test Type:
IMMUNOLOGY
