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Test Name:
Diphtheria and Tetanus IgG Antibodies
- SBMF No:
45552 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
D/T - ABN:
Not required - CPT Code:
86317x2 - LOINC Code:
13227-4; 6367-7 - Ref Lab Test No:
0050595 - Test Includes:
Diphtheria IgG Antibody
Tetanus IgG Antibody - Also Known As:
Tetanus/Diphtheria Antibodies
Tetanus/Diptheria Immune Response
Tetanus/Diptheria Vaccine Response - Also See:
45553 Diphtheria, Tetanus, and H. influenzae b IgG Antibodies
45554 Humoral Immunity Panel - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.15 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Mark specimens clearly as "Pre-Vaccine" or "Post-Vaccine" - Spec Store Transport:
Refrigerated - Spec Stability:
After separation from cells:
2 days room temperture
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Plasma or body fluid sample - Spec Remarks:
Separate serum from cells ASAP or within 2 hours of collection
"Pre" and "post" vaccination specimens should be submitted together for testing.
"Post" specimen should be drawn 30 days after immunization and must be received within 60 days of "pre" specimen. - Methodology:
Quantitative Multi-Analyte Fluorescence Detection (MAFD) - Clinical Significance:
Refer to:
- Reference Range:
Antibody concentration of > 0.1 IU/mL is usually considered protective for diphtheria or tetanus.
Interpretive Data:
Responder status is determined according to the ratio of a one-month post-vaccination sample to pre-vaccination concentration of IgG antibodies as follows:Diphtheria and tetanus:
1. If the post-vaccination concentration is less than 1.0 IU/mL, the patient is considered a nonresponder.
2. If the post-vaccination concentration is greater than or equal to 1.0 IU/mL, a patient with a ratio of less than 1.5 is a nonresponder, a ratio of 1.5 to less than 3.0, is a weak responder, and a ratio of 3.0 or greater, is a good responder.
3. If the pre-vaccination concentration is greater than 1.0 IU/mL, it may be difficult to assess the response based on a ratio alone. A post-vaccination concentration above 2.5 IU in this case is usually adequate. - Day Run:
Sun-Sat (daily) - Time Reported:
2-3 days - Test Type:
INFECTIOUS ANTIBODY
