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Test Name:
Doxepin and Nordoxepin, Serum or Plasma


  • SBMF No:
    45507
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    DOXEPIN-
  • ABN:
    Not required
  • CPT Code:
    80166; 80299
  • LOINC Code:
    3579-0; 3862-0; 3582-4
  • Ref Lab Test No:
    0090102
  • Test Includes:
    Doxepin
    Nordoxepin
  • Also Known As:
    Adapin, Nordoxepin, Prudoxin, Sinequan, Zonalon
  • Also See:
    29140 Tricyclic Antidepressants, Qualitative, Serum
    44924 Tricyclic Antidepressants, Quantitative, Serum or Plasma
  • Spec Type:
    Serum
  • Spec Container:
    Red top (serum) tube
  • Alt Spec Type:
    Plasma
  • Alt Spec Container:
    Lavender top (EDTA), green top (sodium heparin), or gray top (fluoride/oxalate) tube
  • Pref Vol:
    2.0 mL
  • Min Vol:
    0.5 mL
  • Fasting:
    No
  • Spec Collect:
    Avoid use of gel-barrier tubes
    Routine venipuncture
  • Spec Process:
    Serum sample tubes, clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum or plasma to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    After separation from cells:
    5 days room temperature (20-30°C)
    2 weeks refrigerated (2-8°C)
    6 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Sample collected and stored in gel-barrier tube for more than 2 hours at room temperature
    Sample refrigerated in a gel-barrier tube for more than 30 minutes
  • Spec Remarks:
    If gel-barrier tube is used, separate serum or plasma from gel within two hours of collection. Do not refrigerate in gel-barrier tube.
  • Methodology:
    Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  • Use:
    Therapeutic drug monitoring
  • Reference Range:
    Therapeutic Range:
    Doxepin & nordoxepin: 100-300 ng/mL
  • Critical High Value:
    Toxic: > 400 ng/mL
  • Day Run:
    Sun-Sat (daily)
  • Time Reported:
    2-3 days
  • Test Type:
    TOX-TDM