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Test Name:
Nortriptyline, Serum or Plasma
- SBMF No:
45502 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
NORT HPLC - ABN:
Not required - CPT Code:
80182 - LOINC Code:
3872-9 - Ref Lab Test No:
0090074 - Also Known As:
Allegron, Aventyl, Noritren, Norpress, Nortrilen, Pamelor, Sensoval - Also See:
45501 Amitriptyline and Nortriptyline, Serum or Plasma
29140 Tricyclic Antidepressants, Qualitative, Serum
44924 Tricyclic Antidepressants, Quantitative, Serum or Plasma - Spec Type:
Serum - Spec Container:
Red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (EDTA), green top (sodium heparin), or gray top (fluoride/oxalate) tube - Pref Vol:
2.0 mL - Min Vol:
0.6 mL - Fasting:
No - Spec Collect:
Avoid use of gel-barrier tubes
Routine venipuncture - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
After separation from cells:
5 days room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
6 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Sample collected and stored in gel-barrier tube for more than 2 hours at room temperature
Sample refrigerated in a gel-barrier tube for more than 30 minutes - Spec Remarks:
Do not order if amitriptyline is administered; instead order Amitriptyline and Nortriptyline (45501)
If gel-barrier tube is used, separate serum or plasma from gel within two hours of collection. Do not refrigerate in gel-barrier tube. - Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) - Use:
Therapeutic drug monitoring - Reference Range:
Therapeutic Range: 50-150 ng/mL - Critical High Value:
Toxic: > 500 ng/mL - Day Run:
Sun-Sat (daily) - Time Reported:
2-3 days - Test Type:
TOX-TDM
