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Test Name:
Rickettsia typhi IgG and IgM Antibodies, by IFA
- SBMF No:
45393 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
TYPHU G/M - ABN:
Not required - CPT Code:
86757x2 - LOINC Code:
5324-9; 5325-6 - Ref Lab Test No:
0050384 - Test Includes:
Rickettsia typhi IgG Antibody
Rickettsia typhi IgM Antibody - Also Known As:
Typhus Fever IgG and IgM Antibodies - Also See:
45391 – Rickettsia typhi IgG Antibody, by IFA
45392 – Rickettsia typhi IgM Antibody, by IFA - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL
Pediatric Collection: 0.15 mL - Fasting:
No - Spec Collect:
Routine venipuncture
Parallel testing is preferred
Label samples as: "acute" or "convalescent"
Convalescent samples must be received within 30 days from receipt of acute samples - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
After separation from cells:
48 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Severely lipemic, contaminated, or hemolyzed sample - Methodology:
Indirect Fluorescent Antibody (IFA) - Use:
Acute and convalescent titers are often necessary to document disease - Clinical Significance:
Refer to:
- Reference Range:
Rickettsia typhi (Typhus Fever) IgG Antibody, by IFA < 1:64 Negative No significant level of Rickettsia typhi IgG antibody detected. 1:64 - 1:128 Equivocal Questionable presence of Rickettsia typhi IgG antibody detected. Repeat testing in 10-14 days may be helpful. ≥ 1:256 Positive Presence of IgG antibody to Rickettsia typhi detected, suggestive of current or past infection. Rickettsia typhi (Typhus Fever) IgM Antibody, by IFA < 1:64 Negative No significant level of Rickettsia typhi IgM antibody detected. ≥ 1:64 Positive Presence of IgM antibody to Rickettsia typhi detected, suggestive of recent infection. - Additional Test Info:
These tests are for antibodies to Rickettsia typhi. Any antibody reactivity to Rickettsia typhi antigen should, however, also be considered group-reactive for the Typhus Fever group (Rickettsia prowazekii). Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change (fourfold difference in titer) on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.
While the presence of IgM antibodies suggests current or recent infection, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.
- Day Run:
Tue, Fri - Time Reported:
2-6 days - Test Type:
INFECTIOUS ANTIBODY
