South Bend Medical Foundation - Your Community Laboratory

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Test Name:
Febrile Antibodies Panel

• SBMF No:
  45389
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  FEB AB
• ABN:
  Not required
• CPT Code:
  86622; 86757x4; 86768x5
• LOINC Code:
  13284-5; 19053-8; 5307-4; 5308-2; 5324-9; 5325-6; 19146-0; 19146-0; 13285-2; 57769-2
• Ref Lab Test No:
  2001789
• Test Includes:
  Brucella Antibody
  Rickettsia rickettsii (Rocky Mountain Spotted Fever) IgG & IgM Antibodies
  Rickettsia typhi (Typhus Fever) IgG & IgM Antibodies
  Salmonella typhi Antibodies
• Also See:
  44605 Brucella Antibody
  44410 Rickettsia rickettsii IgG & IgM Antibodies, by IFA
  45393 Rickettsia typhi IgG & IgM Antibodies, by IFA
  45141 Salmonella typhi Antibodies
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Pref Vol:
  2.5 mL
• Min Vol:
  1.5 mL
• Fasting:
  No
• Spec Collect:
  Routine venipuncture
  Parallel testing is preferred
  Label samples as: "acute" or "convalescent"
  Convalescent samples must be received within 30 days from receipt of acute samples
• Spec Process:
  Clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  48 hours room temperature (20-30°C)
  2 weeks refrigerated (2-8°C)
  1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Contaminated or heat-inactivated sample
• Spec Remarks:
  Remove serum from cells ASAP
• Methodology:
  Direct Agglutination (DA)
  Indirect Fluorescent Antibody (IFA)
  ImmunoDOT
• Clinical Significance:
  Refer to:
  
• Reference Range:
  

  Brucella Total Antibody, by Agglutination
  < 1:20 Negative

  Rickettsia rickettsii (Rocky Mountain Spotted Fever) IgG Antibody
  Less than 1:64: Negative - No significant level of Rickettsia rickettsii Antibody, IgG detected.
  1:64 - 1:128: Low Positive - Presence of Rickettsia rickettsii Antibody, IgG detected, suggestive of current or past infection.
  1:256 or greater: Positive - Presence of Rickettsia rickettsii Antibody, IgG suggestive of recent or current infection.

  Rickettsia rickettsii (Rocky Mountain Spotted Fever) IgM Antibody
  Less than 1:64: Negative - No significant level of Rickettsia rickettsii Antibody, IgM detected.
  1:64 or greater: Positive - Presence of Rickettsia rickettsii Antibody, IgM detected, which may indicate a current or recent infection; however, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

  Rickettsia typhi (Typhus Fever) IgG Antibody
  < 1:64 Negative - No significant level of Rickettsia typhi IgG antibody detected.
  1:64-1:128 Equivocal - Questionable presence of Rickettsia typhi IgG antibody detected. Repeat testing in 10-14 days may be helpful.
  ≥ 1:256 Positive - Presence of IgG antibody to Rickettsia typhi detected, suggestive of current or past infection.

  Rickettsia typhi (Typhus Fever) IgM Antibody
  < 1:64 Negative - No significant level of Rickettsia typhi IgM antibody detected.
  ≥ 1:64 Positive - Presence of IgM antibody to Rickettsia typhi detected, suggestive of recent infection.

  Salmonella typhi H type A Total Antibody
  Negative

  Salmonella typhi H type B Total Antibody
  Negative

  Salmonella typhi H type D Total Antibody
  Negative

  Salmonella typhi O type D Total Antibody
  Negative

  Salmonella typhi O type Vi Total Antibody
  Negative

• Day Run:
  Mon-Fri
• Time Reported:
  3-6 days
• Test Type:
  INFECTIOUS ANTIBODY