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Test Name:
Gonadotropin Releasing Hormone


  • SBMF No:
    45351
  • Performance Lab Name:
    Inter Science Institute
  • Test Mnemonic:
    GNRH
  • ABN:
    Not required
  • CPT Code:
    83727
  • LOINC Code:
    19146-0
  • Ref Lab Test No:
    Quest# S43700
  • Also Known As:
    GnRH
    Luteinizing Hormone-Releasing Hormone (LH-RH)
  • Spec Type:
    Serum
  • Spec Container:
    Red top (serum) tube
  • Alt Spec Type:
    Plasma
  • Alt Spec Container:
    Lavender top (EDTA) tube
  • Pref Vol:
    3.0 mL
  • Min Vol:
    1.0 mL
  • Fasting:
    No
  • Patient Prep:
    If possible, patient should not be on any steroid, ACTH, gonadotropin, or estrogen medications for at least 48 hours prior to sample collection
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Serum sample tubes, clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum or plasma to separate plastic tube and freeze
  • Spec Store Transport:
    Frozen and on dry ice
  • Spec Stability:
    Room temperature (20-30°C): Unacceptable
    Refrigerated (2-8°C): Unacceptable
    1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Remarks:
    For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact Inter Science Institute for requirements and special handling
  • Methodology:
    Radioimmunoassay (RIA)
  • Clinical Significance:
    Luteinizing Hormone-Releasing Hormone (LH-RH), also known as Gonadotropin-Releasing Hormone (Gn-RH), is a decapeptide secreted pulsatily from the hypothalamus. It stimulates the release of the Gonadotropins - Luteinizing Hormone and Follicle Stimulating Hormone - exerting a stronger effect on Luteinizing Hormone. Testosterone and Estradiol, whose release is stimulated by the Gonadotropins, exert a negative feedback control on LH-RH both at the hypothalamic site and by decreasing pituitary receptor binding. LH-RH levels are low in patients with hypothalamic hypogonadism differentiating them from the high levels usually found in primary hypopituitary hypogonadism. Accentuation of the LH-RH pulse occurs at the onset of puberty triggering the release of LH and FSH required in pubertal development. LH-RH is stimulated by Epinephrine and suppressed by Dopamine and opiates. LH-RH and some of its agonists are frequently used to induce ovulation.
  • Reference Range:
    Luteinizing Hormone-Releasing Hormone
    (LH-RH, Gonadotropin Releasing Hormone, Gn-RH)
    Male: 4.0 - 8.0 pg/mL
    Female: 2.0 - 10.0 pg/mL
  • Additional Test Info:
    This test is referred through Quest Diagnostics Nichols Institute.
  • Day Run:
    Mon-Fri
  • Time Reported:
    3 days
  • Test Type:
    HORMONE

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