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Test Name:
Tiagabine, Serum or Plasma
- SBMF No:
45343 - Performance Lab Name:
MedTox Scientific - Test Mnemonic:
TIAGABIN S - ABN:
Not required - CPT Code:
80299 - LOINC Code:
19146-0 - Ref Lab Test No:
409 (ARUP# 0091541) - Also Known As:
Gabitril® - Spec Type:
Serum - Spec Container:
Red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Green top (heparin) tube - Pref Vol:
3.0 mL - Min Vol:
1.0 mL - Fasting:
No - Spec Collect:
Do not use gel-barrier tubes for specimen collection
Routine venipuncture
Trough levels are most reproducible - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
2 weeks room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
7 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Sample collected in gel-barrier tube - Methodology:
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) - Use:
Therapeutic drug monitoring - Clinical Significance:
Antiepileptic (Anticonvulsant) - Reference Range:
Reporting Limit: 5.0 ng/mL
Interpretive Data:
Reference Range: < 235.0 ng/mL- Therapeutic and toxic ranges have not been established. Peak concentrations are expected at 45 minutes post dose; steady state is generally attained within 2 days. Observed tiagabine concentrations in clinical trials (30-56 mg/day): < 1 - 234 ng/ml. Measured tiagabine concentrations, post marketing (95% confidence interval): 0 - 440 ng/mL.
Note:
The 95% confidence interval for tiagabine concentrations determined by MEDTOX Laboratories will be updated periodically as more information becomes available. - Additional Test Info:
This test is referred through ARUP Laboratories - Day Run:
Varies - Time Reported:
Varies - Test Type:
TOX-TDM
