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Test Name:
Vitamin B3 (Niacin)
- SBMF No:
45282 - Performance Lab Name:
Cambridge Biomedical Inc - Test Mnemonic:
NIACIN B3 - ABN:
Required – Not FDA-Approved - CPT Code:
84591 - LOINC Code:
19146-0 - Ref Lab Test No:
ARUP# 0092168 - Also Known As:
Niacin
Nictonic Acid - Spec Type:
Plasma - Spec Container:
Lavender top (EDTA) tube - Pref Vol:
4.0 mL - Min Vol:
2.0 mL - Fasting:
No - Spec Collect:
Routine venipuncture
Protect sample from light - Spec Process:
Promptly centrifuge 15 minutes
Immediately, transfer plasma to light-protected (amber) plastic tube and freeze - Spec Store Transport:
Frozen
Protected from light - Spec Stability:
After separation from cells:
Room temperature (20-30°C): Unacceptable
3 days refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Grossly hemolyzed or lipemic specimen
Thawed specimen or specimen not protected from light - Spec Remarks:
CRITICAL FROZEN – Separate specimens must be submitted when multiple tests are ordered
Protect sample from light during collection, storage, and shipment - Methodology:
High Performance Liquid Chromatography (HPLC) - Clinical Significance:
The amino acid tryptophan can be metabolically converted into niacin. Vitamin B3, also called niacin and nicotinic acid, is a water soluble B vitamin. It plays a role in releasing energy from carbohydrates and fats, metabolizes proteins, and assists in the production of some hormones and in the formation of red blood cells. Niacin is also thought to prevent and treat diabetes; improve circulation (as inositol hexaniacinate); and relieve arthritis.
Niacin deficiency causes pellagra. Other forms of niacin may help prevent the development of childhood diabetes (Type I) in high risk children.
The beneficial use of niacin (nicotinic acid, but not niacinamide) to prevent or treat elevated blood lipids and reduce cardiovascular disease risk is documented. Large amounts of niacin may result in “niacin intolerance” in 15-40% of people who try it and the unpleasant side effect of “skin-flushing” (similar to hot flashes). The RDA for niacin is only 13 – 18 mg. Vitamin B3 has been used orally and intravenously in connection with various health conditions including: high triglycerides, dysmenorrheal, hypothyroidism and multiple sclerosis.
- Reference Range:
By report - Additional Test Info:
The performance characteristics of the listed assay was validated by Cambridge Biomedical Inc. The US FDA has not approved or cleared this test. The results of these assay can be used for clinical diagnosis without FDA approval. Cambridge Biomedical is a CLIA certified, CAP accredited laboratory for performing high complexity assays such as this one.
This test is referred through ARUP Laboratories
- Day Run:
Varies - Time Reported:
Varies - Test Type:
CHEMISTRY
