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Test Name:
Toxoplasma IgG Antibody, Dye Test
- SBMF No:
45196 - Performance Lab Name:
Toxoplasma Serology Laboratory, Palo Alto Medical Foundation - Test Mnemonic:
TOXO G DYE - ABN:
Not required - CPT Code:
86777 - Also Known As:
Sabin-Feldman Dye Test - Also See:
28137 Toxoplasma IgG & IgM Antibodies, Serum - Spec Type:
Serum - Spec Container:
Red top (serum) tube - Alt Spec Type:
Cerebrospinal Fluid (CSF) - Alt Spec Container:
Plastic tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Blood: Routine venipuncture
Cerebrospinal fluid: Collected by physician - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube - Spec Store Transport:
Refrigerated (2-8°C) preferred
Room temperature or frozen acceptable - Methodology:
Sabin-Feldman Dye Test - Use:
Serologic confirmation of exposure to Toxoplasma gondii - Clinical Significance:
The Dye Test (DT) is a sensitive and specific neutralization test in which live organisms are lysed in the presence of complement and the patient's IgG T. gondii-specific antibody. IgG antibodies usually appear within 1 to 2 weeks of the infection, peak within 1 to 2 months, fall at variable rates, and usually persist for life. The titer does not correlate with the severity of illness.
A positive DT establishes that the patient has been exposed to the parasite. A negative DT essentially rules out prior exposure to T. gondii (unless the patient is hypogammaglobulinemic). However, in a small number of patients, IgG antibodies might not be detected within 2 to 3 weeks after the initial exposure to the parasite. In addition, rare cases of toxoplasmic chorioretinitis and TE (toxoplasmic encephalitis) in immunocompromised patients have been documented in patients negative for T. gondii-specific IgG antibodies.
- Reference Range:
Negative < 1:16
Positive > or = 1:16 - Day Run:
Mon, Wed - Time Reported:
Within 6 days - Test Type:
INFECTIOUS ANTIBODY
