South Bend Medical Foundation - Your Community Laboratory

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Test Name:
Tramadol and Metabolites, Serum or Plasma

• SBMF No:
  44914
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  TRAMAD SP
• ABN:
  Not required
• CPT Code:
  83925
• LOINC Code:
  19146-0; 19146-0; 19146-0
• Ref Lab Test No:
  2002764
• Test Includes:
  Tramadol
  n-desmethyltramadol (qualitative only)
  o-desmethyltramadol (qualitative only)
• Also Known As:
  Ryzolt
  Topalgic
  Tramal
  Ultracet (Tramadol component)
  Ultram
  Zamudol
• Spec Type:
  Plasma
• Spec Container:
  Gray top (fluoride/oxalate), green top (sodium heparin), or lavender top (EDTA) tube
• Alt Spec Type:
  Serum
• Alt Spec Container:
  Red top (serum) tube
• Pref Vol:
  2.0 mL
• Min Vol:
  1.0 mL
• Fasting:
  No
• Spec Collect:
  Routine venipuncture
• Spec Process:
  Serum sample tubes, clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum or plasma to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  1 week room temperature (20-30°C)
  2 weeks refrigerated (2-8°C)
  3 years frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Sample exposed to repeated freeze/thaw cycles
  Sample collected in gel-barrier tube or light blue top (sodium citrate) tube
• Spec Remarks:
  Remove serum/plasma from cells ASAP
• Methodology:
  Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
• Use:
  Therapeutic Drug Monitoring
• Clinical Significance:
  Refer to:
  
• Reference Range:
  

  Interpretive Data:

  Drugs covered:	Tramadol, n-desmethyltramadol (qualitative only), and o-desmethyltramadol (qualitative only).
  Positive cutoff:	Tramadol: 20 ng/mL n-desmethyltramadol: 50 ng/mL o-desmethyltramadol: 50 ng/mL

  For medical purposes only; not valid for forensic use.

  The presence of metabolite(s) without parent drug may indicate use of parent drug during the prior week.

  The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

• Day Run:
  Tue
• Time Reported:
  2-8 days
• Test Type:
  TOX-TDM