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Test Name:
Buprenorphine and Metabolites, Serum or Plasma

• SBMF No:
  44910
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  BUPREN SP
• ABN:
  Not required
• CPT Code:
  83925
• LOINC Code:
  53881-9; 19146-0; 3413-2; 19146-0
• Ref Lab Test No:
  2002742
• Test Includes:
  Buprenorphine
  Norbuprenorphine
  Buprenorphine glucuronide (qualitative only)
  Norbuprenorphine glucuronide (qualitative only)
• Also Known As:
  Buprenex, Buprenorphine, Buprenorphine Glucuronide, Butrans, Norbuprenorphine, Norbuprenorphine Glucuronide, Norspan, Suboxone, Subutex, Temgesic, Transtec, Vetergesic
• Spec Type:
  Serum or plasma
• Spec Container:
  Gray top (fluoride/oxalate) tube; Also acceptable: Red top (serum), Green top (sodium heparin), or Lavender top (EDTA) tube
• Pref Vol:
  2.0 mL
• Min Vol:
  1.0 mL
• Fasting:
  No
• Spec Collect:
  Do not use gel-barrier tubes for specimen collection
  Routine venipuncture
• Spec Process:
  Serum sample tubes, clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum or plasma to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  1 week room temperature (20-30°C)
  2 weeks refrigerated (2-8°C)
  3 years frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Specimen collected in polymer gel separation tube
  Specimen collected in light blue top (sodium citrate) tube
  Specimen exposed to repeated freeze/thaw cycles
• Spec Remarks:
  Separate serum or plasma from cells ASAP or within 2 hours of collection
• Methodology:
  Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
• Use:
  Therapeutic Drug Monitoring
• Clinical Significance:
  Refer to:
  
• Reference Range:
  

  Interpretive Data:

  Drugs covered:	Buprenorphine, norbuprenorphine, buprenorphine glucuronide (qualitative only), and norbuprenorphine glucuronide (qualitative only).
  Positive cutoff:	Buprenorphine: 2 ng/mL Norbuprenorphine: 2 ng/mL Buprenorphine glucuronide: 5 ng/mL Norbuprenorphine glucuronide: 5 ng/mL

  For medical purposes only; not valid for forensic use.

  The presence of metabolite(s) without parent drug may indicate use of parent drug during the prior week.

  The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

• Day Run:
  Sun-Sat (daily)
• Time Reported:
  2-5 days
• Test Type:
  TOX-TDM