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Test Name:
Glomerular Basement Membrane IgA Antibody, by IFA

• SBMF No:
  44792
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  GBM-A IFA
• ABN:
  Required – Not FDA-Approved
• CPT Code:
  86255
• Ref Lab Test No:
  0049192
• Also Known As:
  Anti-GBM IgA Antibody
  Anti-Glomerular Basement Membrane IgA Antibody
  GBM IgA Antibody
• Also See:
  44795 Glomerular Basement Membrane Antibody Panel
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Pref Vol:
  1.0 mL
• Min Vol:
  0.5 mL
• Fasting:
  No
• Spec Collect:
  Routine venipuncture
• Spec Process:
  Clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  48 hours room temperature (20-30°C)
  2 weeks refrigerated (2-8°C)
  1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Remarks:
  Separate serum from cells ASAP
• Methodology:
  Indirect Fluorescent Antibody (IFA)
• Clinical Significance:
  Refer to:
  
• Reference Range:
  Negative

  Interpretive Data:
  The anti-GBM IFA methodology has been shown to be less specific than the quantitative tests for circulating antibodies such as the Multi-Analyte Fluorescent Detection (MAFD). The antibody used in this assay, although directed to human IgG F(ab')2, can bind to light chain sites common to all immunoglobulins causing it to be more sensitive but less specific. The determination of a positive result is based upon a diffuse "linear" staining pattern as viewed through a fluorescent microscope, all positive results should be confirmed by quantitative tests and/or renal biopsy.

• Additional Test Info:
  This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
• Day Run:
  Mon-Fri
• Time Reported:
  Within 6 days
• Test Type:
  IMMUNOLOGY