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Test Name:
Natural Killer Cell Panel
- SBMF No:
44724 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
NK PROFILE - ABN:
Not required - CPT Code:
86356x8 - LOINC Code:
8101-8; 8118-2; 8124-0; 8132-3; 8135-6; 19146-0; 19146-0; 19146-0; 19146-0; 19146-0 - Ref Lab Test No:
2004360 - Test Includes:
% CD2
% CD3
% CD5
% CD7
% CD8
% CD2+/CD16+
% CD3-/CD56+
% CD3-/CD57+
% CD3+/CD56+
% CD3+/CD57+ - Spec Type:
Whole blood - Spec Container:
Green top (heparin) or lavender top (EDTA) tube - Pref Vol:
5.0 mL - Min Vol:
1.0 mL - Fasting:
No - Spec Collect:
Routine venipuncture
Time Sensitive – Avoid collection on weekends or holidays when shipment to the reference lab may be delayed - Spec Process:
Gently invert tube to mix blood with the anticoagulant
Do not centrifuge
Do not remove plasma from cells
Forward entire tube of unprocessed whole blood to the laboratory - Spec Store Transport:
Room temperature - Spec Stability:
48 hours room temperature (20-30°C)
Refrigerated (2-8°C): Unacceptable
Frozen (-20°C): Unacceptable - Spec Reject:
Clotted, refrigerated, or frozen sample
Sample submitted in pour off tube
Sample collected in yellow top (ACD) tube
Sample older than 48 hours - Spec Remarks:
CRITICAL AMBIENT
Sample must be analyzed within 48 hours of collection - Methodology:
Semi-Quantitative Flow Cytometry - Reference Range:
By report
Interpretive Data:
Natural killer (NK) cells typically express CD2, CD7, CD16, CD56, CD57, and sometimes CD8 but lack expression of CD3 and CD5. NK cells act against virally-infected cells and tumor cells and may be increased or decreased in various immunologic abnormalities. NK-like T-cells have properties of both T-cells and NK-cells, expressing both CD3 and NK-associated antigens. This test reports both NK cell and NK-like T-cell subgroups. The overlapping NK cell subgroup populations reported are CD2+/CD16+, CD3-/CD56+, and CD3-/CD57+. The overlapping NK-like T-cell subgroup populations reported are CD3+/CD56+ and CD3+/CD57+. - Additional Test Info:
ASR Compliance Statement:
Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use. - Day Run:
Sun-Sat (daily) - Time Reported:
2-4 days - Test Type:
FLOW
