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Test Name:
Varicella-Zoster Virus IgM Antibody, Cerebrospinal Fluid
- SBMF No:
44669 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
CSF VZV M - ABN:
Not required - CPT Code:
86787 - LOINC Code:
31695-0 - Ref Lab Test No:
0054445 - Also See:
44516 Varicella-Zoster Virus by PCR - Spec Type:
Cerebrospinal fluid (CSF) - Spec Container:
Plastic transport tube with threaded cap - Pref Vol:
0.5 mL - Min Vol:
0.3 mL - Spec Collect:
Collected by physician - Spec Store Transport:
Refrigerated - Spec Stability:
8 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Heat-inactivated or contaminated sample - Spec Remarks:
CSF is the only acceptable sample type - Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA) - Clinical Significance:
Refer to:
- Reference Range:
0.90 ISR or less: Negative - No significant level of IgM antibody to varicella-zoster virus detected.
0.91-1.09 ISR: Equivocal - Repeat testing in 10-14 days may be helpful.
1.10 ISR or greater: Positive - Significant level of IgM antibody to varicella-zoster virus detected, which may indicate current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.Interpretive Data:
The detection of antibodies to varicella-zoster in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier. - Additional Test Info:
The manufacturer has not determined the efficacy of this test when performed on CSF specimens. The performance characteristics of this test were determined by ARUP laboratories. - Day Run:
Mon-Fri - Time Reported:
2-6 days - Test Type:
INFECTIOUS ANTIBODY
