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Test Name:
Sensory Neuropathy Antibody Panel, with PCCA Titer, ANNA Titer, and Neuronal Immunoblot if Indicated


  • SBMF No:
    44632
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    SENSORY
  • ABN:
    Required – Not FDA-Approved
  • CPT Code:
    86255 PCCA screen, add 86256 (PCCA titer) and 83516 (Immunoblot) if indicated
    83516 MAG IgM ELISA; 83516 SGPG IgM
    86255 ANNA screen, add 86256 (ANNA titer) and 83516 (Immunoblot) if indicated
  • Ref Lab Test No:
    0051222
  • Test Includes:
    Purkinje Cell Ab Screen
    Purkinje Cell Ab Titer (If Indicated)
    PCCA Immunoblot (Anti-Yo) (If Indicated)
    MAG IgM Ab by ELISA
    SGPG IgM Ab by ELISA
    ANNA IgG Screen by IFA
    ANNA IgG Titer by IFA (If Indicated)
    ANNA Immunoblot (Anti-Hu and Anti-Ri) (If Indicated)
  • Also See:
    44373 Purkinje Cell Cytoplasmic Antibody, by IFA, with Titer and Immunoblot if Indicated
    45775 Myelin Associated Glycoprotein (MAG) and Sulfate-3-Glucuronyl Paragloboside (SGPG) IgM Antibodies
    44064 Neuronal Nuclear IgG Antibody, by IFA, with Titer and Immunoblot if Indicated, Serum
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    2.0 mL
  • Min Vol:
    1.0 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube and freeze
  • Spec Store Transport:
    Frozen
  • Spec Stability:
    After separation from cells:
    24 hours room temperature (20-30°C)
    2 weeks refrigerated (2-8°C)
    1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Contaminated, heat-inactivated, hemolyzed, or lipemic sample
    Other body fluids
  • Spec Remarks:
    Separate serum from cells ASAP or within 2 hours of collection
  • Methodology:
    Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
    Semi-Quantitative Indirect Fluorescent Antibody (IFA)
    Qualitative Immunoblot
  • Clinical Significance:
    Refer to:
    ARUP Consult | The Physician's Guide to Laboratory Test Selection and Interpretation
  • Reference Range:

    Purkinje Cell Antibody, Screen
    < 1:10

    Purkinje Cell Antibody, Titer
    < 1:10

    Myelin Associated Glycoprotein (MAG) Antibody, IgM
    Less than 1000 TU

    Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM
    Less than 1.00 IV

    Neuronal Nuclear Antibody (ANNA) IgG Screen, by IFA
    < 1:10

    Neuronal Nuclear Antibody (ANNA) Titer IgG by IFA, Serum
    < 1:10 No antibody detected

    Neuronal Nuclear Antibody IgG, Immunoblot Anti-Hu
    Negative

    Neuronal Nuclear Antibody IgG, Immunoblot Anti-Ri
    Negative

    Neuronal Antibody IgG, Immunoblot Anti-Yo
    Negative

    Note:
    If ANNA IFA is 1:10, then a titer and immunoblot (Hu and Ri) will be added. If Purkinje cell screen is 1:10, then a titer and immunoblot (Yo) will be added. Additional charges apply.

  • Additional Test Info:
    This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
  • Day Run:
    Tue-Thu
  • Time Reported:
    2-10 days
  • Test Type:
    IMMUNOLOGY

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