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Test Name:
Beta-2 Transferrin, by IFE, Serum and Fluid


  • SBMF No:
    44622
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    B2TRNSF
  • ABN:
    Required – Not FDA-Approved
  • CPT Code:
    86334; 86335
  • LOINC Code:
    13876-8
  • Ref Lab Test No:
    0050047
  • Spec Type:
    Serum -plus- Aural or Nasal Fluid
  • Spec Container:
    2 containers:
        Blood: Gold top (SST) tube -plus- Fluid: sterile plastic tube with tightly fitting lid
  • Pref Vol:
    2.0 mL Serum - plus - 2.0 mL Aural or Nasal Fluid
  • Min Vol:
    0.5 mL Serum - plus - 1.0 mL Aural or Nasal Fluid
  • Fasting:
    No
  • Spec Collect:
    Blood: Routine venipuncture
    Fluid: Collect in sterile container without preservative
  • Spec Process:
    Blood:
       - Clot 30 minutes
       - Promptly centrifuge 15 minutes
       - Immediately transfer serum to separate plastic tube
    Fluid: Refrigerate and transport refrigerated
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    4 hours room temperature (20-30°C)
    3 days refrigerated (2-8°C)
    Frozen (-20°C): Unacceptable
  • Spec Reject:
    Plasma samples
    Frozen samples
  • Spec Remarks:
    Separate serum from cells ASAP
  • Methodology:
    Immunofixation Electrophoresis
  • Use:
    Detection of a beta-2 transferrin band by IFE is diagnostic for the presence of cerebrospinal fluid (CSF). This test is a consideration in the differential diagnosis for CSF otorrhea or CSF rhinorrhea. Beta-2 transferrin is not detected in normal serum, tears, saliva, sputum, nasal, aural fluid, or endolymph by this method.
  • Clinical Significance:
    Refer to:
    ARUP Consult | The Physician's Guide to Laboratory Test Selection and Interpretation
  • Reference Range:
    None detected
  • Additional Test Info:
    The performance characteristics of this test were validated by ARUP Laboratories, Inc. The U.S. Food and Drug Administration (FDA) has not approved this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high- complexity testing.
  • Day Run:
    Mon-Fri
  • Time Reported:
    1-4 days
  • Test Type:
    PROTEIN

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