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Test Name:
Herpes Simplex Virus Type 1 IgG Antibody, Cerebrospinal Fluid
- SBMF No:
44587 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
CSF HERP 1 - ABN:
Not required - CPT Code:
86695 - LOINC Code:
19146-0 - Ref Lab Test No:
0050379 - Also Known As:
Herpes Simplex Virus (HSV) Type 1 Glycoprotein G-Specific IgG Antibody, CSF - Also See:
36004 Herpes Simplex Virus, Type 1 and 2, by RT-PCR - Spec Type:
Cerebrospinal fluid (CSF) - Spec Container:
Sterile plastic tube with screw-top cap - Pref Vol:
0.5 mL - Min Vol:
0.2 mL - Spec Collect:
Collected by physician - Spec Store Transport:
Refrigerated - Spec Stability:
8 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Heat-inactivated or contaminated sample - Spec Remarks:
CSF is the only acceptable sample type - Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA) - Clinical Significance:
Refer to:
- Reference Range:
0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past infection.Interpretive Data:
Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a nontype-specific screening test.The detection of antibodies to herpes simplex virus in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94% of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.
- Additional Test Info:
The manufacturer has not determined the efficacy of this test when performed on CSF specimens. The performance characteristics of this test were determined by ARUP laboratories. - Day Run:
Sun-Sat (daily) - Time Reported:
2-3 days - Test Type:
INFECTIOUS ANTIBODY
