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Test Name:
Herpes Simplex Virus IgG and IgM Antibodies with HSV-1 and HSV-2 IgG Antibodies if Indicated, Cerebrospinal Fluid


  • SBMF No:
    44533
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    CSF HERPR
  • ABN:
    Not required
  • CPT Code:
    86694x2
    If indicated, add 86695; 86696
  • LOINC Code:
    13249-8; 63432-9
  • Ref Lab Test No:
    0050364
  • Test Includes:
    HSV Type Non-Specific IgG Ab, CSF
    HSV Type Non-Specific IgM Ab, CSF
    HSV 1 Type-Specific IgG Ab, CSF (If Indicated)
    HSV 2 Type-Specific IgG Ab, CSF (If Indicated)
  • Also Known As:
    Herpes Simplex Virus (HSV) Type 1 and/or 2 Antibodies, IgG and IgM with Reflex to Type 1 and 2 Glycoprotein G-Specific IgG Ab, CSF
  • Also See:
    36004 Herpes Simplex Virus, Type 1 and 2, by RT-PCR
  • Spec Type:
    Cerebrospinal fluid (CSF)
  • Spec Container:
    Sterile plastic tube with screw-top cap
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.5 mL
  • Spec Collect:
    Collected by physician
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    8 hours room temperature (20-30°C)
    2 weeks refrigerated (2-8°C)
    1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Heat-inactivated or contaminated sample
  • Spec Remarks:
    CSF is the only acceptable sample type
  • Methodology:
    Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
    Chemiluminescent Immunoassay
  • Clinical Significance:
    Refer to:
    ARUP Consult | The Physician's Guide to Laboratory Test Selection and Interpretation
  • Reference Range:

    Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM, CSF by ELISA
    0.89 IV or less; Negative - No significant level of detectable HSV IgM antibody.
    0.90-1.09 IV; Equivocal - Questionable presence of IgM antibodies. Repeat testing in 10-14 days may be helpful.
    1.10 IV or greater; Positive - IgM antibody to HSV detected which may indicate a current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

    Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF
    0.89 IV or less: Negative - No significant level of detectable HSV IgG antibody.
    0.90-1.09 IV: Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
    1.10 IV or greater: Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection.

    Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA (HerpeSelect®), CSF
    0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
    0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.
    1.11 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past infection.

    Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA (HerpeSelect®), CSF
    0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
    0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 2. Repeat testing in 10-14 days may be helpful.
    1.11 IV or greater: Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

    Note:
    If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-Specific IgG, CSF and HSV 2 gG-Specific IgG, CSF will be added. Additional charges apply.

  • Additional Test Info:
    The manufacturer has not determined the efficacy of this test when performed on CSF specimens. The performance characteristics of this test were determined by ARUP laboratories.
  • Day Run:
    Sun-Sat (daily)
  • Time Reported:
    2-3 days
  • Test Type:
    INFECTIOUS ANTIBODY