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Test Name:
Plasminogen Activator Inhibitor 1, Activity
- SBMF No:
44522 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
PAI-1 - ABN:
Not required - CPT Code:
85415 - LOINC Code:
5975-8 - Ref Lab Test No:
0098781 - Also Known As:
PAI-1 Activity - Also See:
43184 Plasminogen Activator Inhibitor Genotype - Spec Type:
Platelet-poor plasma (PPP) - Spec Container:
Light Blue top (3.2% buffered sodium citrate) tube - Pref Vol:
1.5 mL - Min Vol:
1.0 mL - Fasting:
Yes - Patient Prep:
Collect specimen between 8 a.m. and 12 p.m. - Spec Collect:
- Routine venipuncture
- • NOTE: Traumatic puncture invalidates sample for coagulation studies and necessitates recollection
• Observe proper collection order for coagulation tests; collect tubes for coagulation studies prior to collecting tubes containing clot activators, additives, or anticoagulants
• Fill light blue top tube to stated tube volume
• If coagulation study is only test ordered, collect 1.0 to 2.0 mL blood into tube for discard, then collect light blue top coagulation study tube(s)
• If multiple coagulation studies are requested, submit additional samples for each coagulation test
• Immediately after collection, gently invert tube to mix
- Spec Process:
- Separate plasma from cells immediately
- • Promptly centrifuge 15 minutes
• Carefully transfer plasma portion of sample to separate plastic tube using plastic pipette
• NOTE: Buffy coat layer of sample must be avoided
• Centrifuge transferred plasma sample again to produce platelet-poor plasma (PPP)
• Use second plastic pipette to carefully transfer PPP sample into plastic aliquot tubes
• Immediately freeze PPP samples
- Spec Store Transport:
Frozen - Spec Stability:
1 hour room temperature (20-30°C)
Refrigerated (2-8°C): Unacceptable
2 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Serum
Hemolyzed specimen or specimen that has been thawed and refrozen - Spec Remarks:
Separate plasma from cells ASAP or within 1 hour of collection
CRITICAL FROZEN – Separate specimens must be submitted when multiple tests are ordered - Methodology:
Bioimmunoassay - Clinical Significance:
Refer to:
- Reference Range:
Less than or equal to 22.0 IU/mL
Interpretive Data:
Plasminogen Activator Inhibitor 1(PAI-1) has diurnal variation, with higher concentration in the morning and decreased concentration in the afternoon. PAI-1 is also an acute phase reactant. The reference interval was established from fasting samples drawn between 8 am and 12 pm.This assay was designed primarily to identify elevated PAI-1 concentrations, which are thought to be a thrombotic risk factor. Concentrations below 2.0 IU/mL are not accurately quantified by this assay. A test result of less than 2.0 IU/mL is not diagnostic of PAI-1 deficiency and may be seen in normal individuals.
- Day Run:
Mon, Wed, Fri - Time Reported:
2-9 days - Test Type:
COAGULATION
