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Test Name:
N-Telopeptide, Cross-Linked, Urine

• SBMF No:
  44463
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  U NTX
• ABN:
  May be required – Medical Necessity
• CPT Code:
  82523
• LOINC Code:
  14115-0; 2161-8
• Ref Lab Test No:
  0070062
• Also Known As:
  NTx
• Spec Type:
  Urine, Second-morning void
• Spec Container:
  Plastic container with tightly fitting lid (no preservative)
• Alt Spec Type:
  Urine, 24-hour
• Alt Spec Container:
  Plastic, container with tightly fitting lid (no preservative)
• Pref Vol:
  1.0 mL aliquot from well-mixed, second-morning void or 24-hour collection
• Min Vol:
  0.5 mL aliquot from well-mixed, second-morning void or 24-hour collection
• Spec Collect:
  Sample must be refrigerated during collection
  Collect without preservative
• Spec Store Transport:
  Frozen
• Spec Stability:
  24 hours at room temperature (20-30°C)
  1 week refrigerated (2-8°C)
  2 years frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Sample contaminated with blood
• Spec Remarks:
  For monitoring therapy, a baseline sample should be collected prior to initiation of therapy
  Subsequent samples for comparison should be collected at the same time of day as the baseline sample
• Methodology:
  Chemiluminescent Immunoassay (CLIA)
• Clinical Significance:
  Refer to:
  
• Reference Range:
  

  Age	Male	Female
  7-9 years	167-578 nM BCE/mM creatinine	201-626 nM BCE/mM creatinine
  10-12 years	152-505 nM BCE/mM creatinine	173-728 nM BCE/mM creatinine
  13-15 years	103-776 nM BCE/mM creatinine	38-515 nM BCE/mM creatinine
  16-17 years	34-313 nM BCE/mM creatinine	20-144 nM BCE/mM creatinine
  18 years and older	21-83 nM BCE/mM creatinine
  Premenopausal		17-94 nM BCE/mM creatinine
  Postmenopausal		26-124 nM BCE/mM creatinine

  Interpretive Data:

  NTx Units = nM BCE/mM creatinine
  
  A decrease of 30-40% from the NTx baseline after three months of therapy is a typical response to anti-resorptive therapy.
  
  NTx = Cross-linked N-telopeptide of Type I Collagen
  BCE = Bone Collagen Equivalent

• Day Run:
  Tue-Sat
• Time Reported:
  2-5 days
• Test Type:
  URINE