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Test Name:
17-Ketosteroids, Urine
- SBMF No:
44454 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
17 KETO - ABN:
Not required - CPT Code:
83586 - LOINC Code:
30211-7; 19153-6; 21038-5; 6766-0; 2161-8; 2162-6 - Ref Lab Test No:
0080650 - Also Known As:
Ketosteroids, Quantitative, Urine
17-KS, Quantitative, Urine - Also See:
30123 DHEA-S (Dehydroepiandrosterone Sulfate) - Spec Type:
Urine, 24-hour - Spec Container:
Plastic container with tightly fitting lid (no preservative) - Alt Spec Type:
Urine, Random - Alt Spec Container:
Plastic, container with tightly fitting lid (no preservative) - Pref Vol:
4.0 mL aliquot from well-mixed 24-hour collection - Min Vol:
3.0 mL aliquot from well-mixed 24-hour collection - Spec Collect:
To begin collection of timed specimen, have patient urinate, noting date and exact time
Discard this first portion of urine, but document date and time of voiding on container label and test requisition as "start" of timed specimen
Save all urine voided during designated time period, including portion voided at exact end of time period
IMPORTANT: Refrigerate entire specimen (2-8°C) during and after collection to prevent bacterial growth
Document date and time of final voiding on label and requisition as "end" of timed specimen - Spec Process:
Upon completion of collection, mix entire specimen well and note 24-hour volume
Pour 4.0 mL of urine into separate plastic tube
Refrigerate urine aliquot and transport refrigerated
Send urine aliquot with notation of 24-hour urine volume on aliquot label and on requisition - Spec Store Transport:
Refrigerated - Spec Stability:
4 hours room temperature (20-30C)
2 weeks refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Remarks:
Adequate refrigeration is the most important aspect of specimen preservation
Preservation can be enhanced by adjusting the pH to 2-4
Adjust the pH by adding an acid, such as 6 mol/L HCl
A pH of < 2 will decrease analyte stability - Methodology:
Spectrophotometry (Zimmerman Reaction) - Use:
Measurement of 17-KS is primarily used in the assessment of adrenal androgen production - Reference Range:
17-Ketostreoids
Male:
0-11 months: 0.0-1.0 mg/d
1-5 years: 1.0-2.0 mg/d
6-10 years: 1.0-4.4 mg/d
11-12 years: 1.3-8.5 mg/d
13-16 years: 3.4-9.8 mg/d
17-50 years: 5.3-17.6 mg/d
51 years and older: 4.1-12.1 mg/d
Female:
0-11 months: 0.0-1.0 mg/d
1-5 years: 1.0-2.0 mg/d
6-10 years: 1.4-3.9 mg/d
11-12 years: 3.8-9.5 mg/d
13-16 years: 4.5-17.1 mg/d
17-50 years: 4.4-14.2 mg/d
51 years and older: 3.2-10.6 mg/dCreatinine (24 hour):
Male:
3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 500-2300 mg/d
18-50 years: 1000-2500 mg/d
51-80 years: 800-2100 mg/d
81 years and older: 600-2000 mg/d
Female:
3-8 years: 140-700 mg/d
9-12 years: 300-1300 mg/d
13-17 years: 400-1600 mg/d
18-50 years: 700-1600 mg/d
51-80 years: 500-1400 mg/d
81 years and older: 400-1300 mg/dInterpretive Data:
Reference intervals for random urine samples (mg/L) are not availableNote:
A large number of substances may interfere with this test. Decreases may be caused by carbamazepine, cephaloridine, cephalothin, chlormerodrin, digoxin, glucose, metyrapone, promazine, propoxyphene, reserpine, and others. Increases may be caused by acetone, acetophenide, ascorbic acid, chloramphenicol, chlorothiazide, chlorpromazine, cloxacillin, dexamethasone, erythromycin, ethinamate, etryptamine, methicillin, methyprylon, morphine, oleandomycin, oxacillin, penicillin, phenaglycodol, phenazopyridine, phenothiazine, piperidine, quinidine, secobarbital, spironolactone, and others. - Additional Test Info:
An alternative and more specific test for adrenal androgen function is Dehydroepiandrosterone Sulfate (Test code 30123). - Day Run:
Mon, Wed, Fri - Time Reported:
2-6 days - Test Type:
URINE
