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Test Name:
Neutrophil-Associated Antibodies, by Flow Cytometry
- SBMF No:
44427 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
ANTI-NEU - ABN:
Not required - CPT Code:
86021 - LOINC Code:
41617-2 - Ref Lab Test No:
0055506 - Also Known As:
Anti-Granulocyte Antibodies
Anti-Neutrophil Antibodies
Granulocyte Antibodies
Neutrophil Antibodies - Also See:
42250 Neutrophil Antibodies, by IFA - Spec Type:
Serum - Spec Container:
Gold top (SST) or Red top (serum) tube - Pref Vol:
3.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Stability:
After separation from cells:
Room temperature: Unacceptable
Refrigerated (2-8°C): Unacceptable
1 month frozen – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Remarks:
Remove serum from cells ASAP or within 2 hours of collection - Methodology:
Qualitative Flow Cytometry - Clinical Significance:
Refer to:
- Reference Range:
Negative
Interpretive Data:
Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty's syndrome, SLE and drug-induced neutropenia. Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens.A positive result on this test is not definitive for specific anti-neutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result. The results of this test should be correlated to clinical history and other data.
Note:
Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive".This test should not be confused with Neutrophil Cytoplasmic IgG Antibodies (28291 - ANCA).
- Additional Test Info:
ASR Compliance Statement:
Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use. - Day Run:
Mon, Wed, Fri - Time Reported:
2-6 days - Test Type:
IMMUNOLOGY
