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Test Name:
Hantavirus IgG and IgM Antibodies, by ELISA, with Sin Nombre Virus (SNV) Specific IgG and/or IgM Antibodies if Indicated
- SBMF No:
44389 - Performance Lab Name:
Focus Diagnostics - Test Mnemonic:
HANTA ABS - ABN:
Required – Not FDA-Approved - CPT Code:
86790x2;
If indicated, add 86790 for each SNV-specific confirmatory assay - LOINC Code:
26620-5; 32131-5 - Ref Lab Test No:
41244 (ARUP# 2001540) - Test Includes:
Hantavirus IgG Antibody
Hantavirus IgM Antibody
Sin Nombre Virus (SNV) Specific IgG Antibody (If Indicated)
Sin Nombre Virus (SNV) Specific IgM Antibody (If Indicated) - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.25 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
1 week room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Remarks:
Separate serum from cells ASAP - Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA) - Use:
Detect Hantavirus-specific IgG and IgM in serum samples in which there is a clinical suspicion of hantavirus pulmonary syndrome (HPS) or hemorrhagic fever with renal syndrome (HFRS) - Clinical Significance:
Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus, which causes hantavirus pulmonary syndrome, a severe and possibly fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala viruses) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States.
Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All screen IgM positive samples are then tested for SNV-specific IgM at an additional charge; further, any screen IgM positive samples that are also screen IgG positive are tested for SNV-specific IgG at an additional charge.
A positive result in the screening ELISA but a negative result in the confirmatory assays may indicate reactivity to a hantavirus causing hemorrhagic fever with renal syndrome.
Also see:
- Reference Range:
<=1.10 - Additional Test Info:
This test was developed and its performance characteristics determined by Focus Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.
This test is referred through ARUP Laboratories
- Day Run:
Varies - Time Reported:
Varies - Test Type:
INFECTIOUS ANTIBODY
