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Test Name:
Nicotine and Metabolites, Urine

• SBMF No:
  44352
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  U NICOTINE
• ABN:
  Not required
• CPT Code:
  83887
• LOINC Code:
  3854-7; 10366-3; 33916-8; 33917-6; 33915-0
• Ref Lab Test No:
  0092356
• Test Includes:
  3-Hydroxycotinine
  Anabasine
  Cotinine
  Nicotine
  Nornicotine
• Spec Type:
  Urine, random
• Spec Container:
  Plastic container with tightly fitting lid (no preservative)
• Pref Vol:
  4.0 mL
• Min Vol:
  2.0 mL
• Spec Collect:
  Routine random urine collection
• Spec Store Transport:
  Room temperature
• Spec Stability:
  10 days room temperature (20-30°C)
  10 days refrigerated (2-8°C)
  8 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Sample exposed to repeated freeze/thaw cycles
• Methodology:
  Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
• Clinical Significance:
  Refer to:
  
• Reference Range:
  

  	Unexposed non- tobacco user	Passive exposure	Abstinent user for greater   than 2 weeks	Active tobacco product use
  Nicotine	Less than 2 ng/mL	Less than 20 ng/mL	Less than 30 ng/mL	1000-5000 ng/mL
  Cotinine	Less than 5 ng/mL	Less than 20 ng/mL	Less than 50 ng/mL	1000-8000 ng/mL
  3-OH-Cotinine	Less than 50 ng/mL	Less than 50 ng/mL	Less than 120 ng/mL	3000-25000 ng/mL
  Nornicotine	Less than 2 ng/mL	Less than 2 ng/mL	Less than 2 ng/mL	30-900 ng/mL
  Anabasine	Less than 3 ng/mL	Less than 3 ng/mL	Less than 3 ng/mL	3-500 ng/mL
  Adapted from Clinical Chemistry 2002;48:1460-71.

  Interpretive Data:
  The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

  For medical purposes only; not valid for forensic use.

• Day Run:
  Sun-Sat (daily)
• Time Reported:
  2-5 days
• Test Type:
  TOX-TDM