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Test Name:
Streptococcus pneumoniae IgG Antibodies, 14 serotypes
- SBMF No:
44342 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
PNEUM AB G - ABN:
Not required - CPT Code:
86317x14 - LOINC Code:
27118-9; 27113-0; 30153-1; 27374-8; 27395-3; 27390-4; 27389-6; 27096-7; 25296-5; 27392-0; 27387-0; 42771-6; 27092-6; 27094-2; 31183-7 - Ref Lab Test No:
0050725 - Test Includes:
Serotypes 1, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 12F, 14, 18C, 19F, 23F - Also Known As:
Pneumococcal IgG Antibodies (14 serotypes)
Streptococcus pneumoniae Immune Response
Streptococcus pneumoniae Vaccine Response - Also See:
45554 Humoral Immunity Panel - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.5 mL - Min Vol:
0.25 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
After separation from cells:
2 days room temperture
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Plasma or body fluid sample
Severely lipemic, contaminated, or hemolyzed sample - Spec Remarks:
Separate serum from cells ASAP
"Pre" and "post" vaccination specimens should be submitted together for testing.
"Post" specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of "pre" specimen.
PLEASE CLEARLY MARK SPECIMENS "PRE-VACCINE" OR "POST-VACCINE" SO THAT SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY. - Methodology:
Multi-Analyte Fluorescence Detection (MAFD) - Clinical Significance:
Refer to:
- Reference Range:
Includes Serotypes 1, 3, 4*, 5, 6B*, 7F, 8, 9N, 9V*, 12F, 14*, 18C*, 19F*, 23F*
All serotypes tested are present in the 23-valent pure polysaccharide pneumococcal vaccine. The serotypes marked with an asterisk are contained in the conjugated pneumococcal vaccine.
This assay is designed to use both "pre" and "post" specimens to assess immune responsiveness to vaccination. This test is not designed to determine protection to Streptococcus pneumoniae based on a single specimen.
Interpretive Data:
Long-term protection is generally thought to be associated with a one month post-vaccine response of at least 1 µg/mL in children and adults. Responder status is determined, once reaching the minimum level of 1 µg/mL, according to the ratio of postvaccination to prevaccination concentration of pneumococcal IgG antibody as follows:A ratio of less than twofold is considered a nonresponder.
A ratio of two- to fourfold is a weak responder
A ratio of fourfold or greater is a good responder. - Day Run:
Mon, Thu, Sat - Time Reported:
2-5 days - Test Type:
INFECTIOUS ANTIBODY
