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Test Name:
Ehrlichia chaffeensis IgG and IgM Antibodies, by IFA
- SBMF No:
44332 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
E CHAF ABS - ABN:
Required – Not FDA-Approved - CPT Code:
86666x2 - LOINC Code:
9783-2; 9784-0 - Ref Lab Test No:
0051002 - Test Includes:
Ehrlichia chaffeensis IgG Antibody, by IFA
Ehrlichia chaffeensis IgM Antibody, by IFA - Also Known As:
Human Monocytic Ehrlichiosis IgG and IgM Antibodies
HME IgG and IgM Antibodies - Also See:
44328 Ehrlichia chaffeensis IgG Antibody, by IFA
44329 Ehrlichia chaffeensis IgM Antibody, by IFA - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.05 mL - Fasting:
No - Spec Collect:
Routine venipuncture
Parallel testing is preferred
Label samples as: "acute" or "convalescent"
Convalescent samples must be received within 30 days from receipt of acute samples - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
After separation from cells:
48 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Contaminated, hemolyzed, or severely lipemic specimen - Spec Remarks:
Separate serum from cells ASAP or within 2 hours of collection - Methodology:
Semi-Quantitative Indirect Fluorescent Antibody (IFA) - Clinical Significance:
Refer to:
- Reference Range:
Ehrlichia chaffeensis Antibody, IgG by IFA
< 1:64 Negative-No significant level of Ehrlichia chaffeensis IgG antibody detected.
1:64-1:128 Equivocal-Questionable presence of Ehrlichia chaffeensis IgG antibody detected. Repeat testing in 10-14 days may be helpful.
≥1:256 Positive-Presence of IgG antibody to Ehrlichia chaffeensis detected, suggestive of current or past infection.Ehrlichia chaffeensis Antibody, IgM by IFA
< 1:16 Negative-No significant level of Ehrlichia chaffeensis IgM antibody detected.
≥ 1:16 Positive-Presence of IgM antibody to Ehrlichia chaffeensis detected, suggestive of current or recent infection.Interpretive Data:
Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change (fourfold difference in titer) on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.While the presence of IgM antibodies suggests current or recent infection, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection. A single IgM result should be interpreted with caution.
Note:
Human ehrlichiosis is a tick-borne disease caused by rickettsial-like agents. Two forms, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), have been described. HME is often referred to as "spotless" or rashless Rocky Mountain spotted fever, and has been reported in various regions of the United States. The causative agent of HME has been identified as Ehrlichia chaffeensis. Infected individuals produce specific antibodies to Ehrlichia chaffeensis which can be detected by an immunofluorescent antibody (IFA) test. - Additional Test Info:
This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. - Day Run:
Tue, Fri - Time Reported:
2-6 days - Test Type:
INFECTIOUS ANTIBODY
