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Test Name:
Saccharomyces cerevisiae IgG and IgA Antibodies


  • SBMF No:
    44238
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    SC PAN
  • ABN:
    Not required
  • CPT Code:
    86671x2
  • LOINC Code:
    47321-5; 47320-7
  • Ref Lab Test No:
    0050564
  • Also Known As:
    ASCA
    IBD Antibodies
  • Also See:
    44237 IBD Profile
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    0.5 mL
  • Min Vol:
    0.3 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    After separation from cells:
    48 hours room temperature (20-30°C)
    2 weeks refrigerated (2-8°C)
    1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Severely lipemic, contaminated, heat-inactivated, or hemolyzed sample
  • Spec Remarks:
    Separate serum from cells ASAP
  • Methodology:
    Enzyme-Linked Immunosorbent Assay (ELISA)
  • Clinical Significance:
    Refer to:
    ARUP Consult | The Physician's Guide to Laboratory Test Selection and Interpretation
  • Reference Range:

    Saccharomyces cerevisiae Antibody, IgA
    20.0 Units or less: Negative
    20.1-24.9 Units: Equivocal
    25.0 Units or greater: Positive

    Saccharomyces cerevisiae Antibody, IgG
    20.0 Units or less: Negative
    20.1-24.9 Units: Equivocal
    25.0 Units or greater: Positive

    Interpretive Data:
    Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.

    Note:
    This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.

  • Day Run:
    Sun-Sat (daily)
  • Time Reported:
    2-3 days
  • Test Type:
    IMMUNOLOGY

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