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Test Name:
IBD Profile


  • SBMF No:
    44237
  • Performance Lab Name:
    ARUP Laboratories
  • Test Mnemonic:
    IBD
  • ABN:
    Not required
  • CPT Code:
    86255; 86671x2
  • LOINC Code:
    14278-6; 47321-5; 47320-7; 19146-0
  • Ref Lab Test No:
    0050567
  • Test Includes:
    Saccharomyces cerevisiae IgA & IgG Antibodies
    Anti-Neutrophil Cytoplasmic Antibody, Atypical Pattern
  • Also Known As:
    IBD Differentiation Profile
    Inflammatory Bowel Disease Profile
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    1.5 mL
  • Min Vol:
    0.6 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    After separation from cells:
    48 hours room temperature (20-30°C)
    2 weeks refrigerated (2-8°C)
    1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Severely lipemic, contaminated, heat-inactivated, or hemolyzed sample
  • Spec Remarks:
    Separate serum from cells ASAP
  • Methodology:
    Enzyme-Linked Immunosorbent Assay (ELISA)
    Indirect Fluorescent Antibody (IFA)
  • Clinical Significance:
    Refer to:
    ARUP Consult | The Physician's Guide to Laboratory Test Selection and Interpretation
  • Reference Range:

    Saccharomyces cerevisiae Antibody, IgA
    20.0 Units or less: Negative
    20.1 to 24.9 Units: Equivocal
    25.0 Units or greater: Positive

    Saccharomyces cerevisiae Antibody, IgG
    20.0 Units or less: Negative
    20.1 to 24.9 Units: Equivocal
    25.0 Units or greater: Positive

    Anti-Neutrophil Cytoplasmic Antibody, Atypical Pattern
    < 1:20: Not significant

    Interpretive Data:
    P-ANCA antibodies are found in 50-70% of ulcerative colitis (UC) patients, but in only 20% of Crohn disease (CD) patients. In contrast, Saccharomyces cerevisiae IgG antibodies are found in 80% of CD patients and 20% of UC patients. Saccharomyces cerevisiae IgA antibodies are found in 35% of CD patients but less than 1% in UC patients.

    Note:
    This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.

  • Day Run:
    Sun, Tue, Thu
  • Time Reported:
    2-5 days
  • Test Type:
    IMMUNOLOGY