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Test Name:
IBD Profile
- SBMF No:
44237 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
IBD - ABN:
Not required - CPT Code:
86255; 86671x2 - LOINC Code:
14278-6; 47321-5; 47320-7; 19146-0 - Ref Lab Test No:
0050567 - Test Includes:
Saccharomyces cerevisiae IgA & IgG Antibodies
Anti-Neutrophil Cytoplasmic Antibody, Atypical Pattern - Also Known As:
IBD Differentiation Profile
Inflammatory Bowel Disease Profile - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.5 mL - Min Vol:
0.6 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
After separation from cells:
48 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Severely lipemic, contaminated, heat-inactivated, or hemolyzed sample - Spec Remarks:
Separate serum from cells ASAP - Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
Indirect Fluorescent Antibody (IFA) - Clinical Significance:
Refer to:
- Reference Range:
Saccharomyces cerevisiae Antibody, IgA
20.0 Units or less: Negative
20.1 to 24.9 Units: Equivocal
25.0 Units or greater: PositiveSaccharomyces cerevisiae Antibody, IgG
20.0 Units or less: Negative
20.1 to 24.9 Units: Equivocal
25.0 Units or greater: PositiveAnti-Neutrophil Cytoplasmic Antibody, Atypical Pattern
< 1:20: Not significantInterpretive Data:
P-ANCA antibodies are found in 50-70% of ulcerative colitis (UC) patients, but in only 20% of Crohn disease (CD) patients. In contrast, Saccharomyces cerevisiae IgG antibodies are found in 80% of CD patients and 20% of UC patients. Saccharomyces cerevisiae IgA antibodies are found in 35% of CD patients but less than 1% in UC patients.Note:
This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease. - Day Run:
Sun, Tue, Thu - Time Reported:
2-5 days - Test Type:
IMMUNOLOGY