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Test Name:
Glomerular Basement Membrane IgG Antibody, by MAFD

• SBMF No:
  44225
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  AGBM AB G
• ABN:
  Not required
• CPT Code:
  83516
• LOINC Code:
  44446-3
• Ref Lab Test No:
  0051000
• Also Known As:
  Anti-GBM IgG Antibody
  Anti-Glomerular Basement Membrane IgG Antibody
  GBM IgG Antibody
• Also See:
  44795 Glomerular Basement Membrane Antibody Panel
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Pref Vol:
  1.0 mL
• Min Vol:
  0.15 mL
• Fasting:
  No
• Spec Collect:
  Routine venipuncture
• Spec Process:
  Clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  48 hours room temperature (20-30°C)
  2 weeks refrigerated (2-8°C)
  1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Remarks:
  Separate serum from cells ASAP
• Methodology:
  Multi-Analyte Fluorescent Detection (MAFD)
• Clinical Significance:
  Refer to:
  
• Reference Range:
  Negative: 19 AU/mL or less
  Equivocal: 20-25 AU/mL
  Positive: 26 AU/mL or greater

  Interpretive Data:
  The presence of anti-glomerular basement membrane (GBM) antibodies by multi-analyte fluorescent detection (MAFD) may aid in the diagnosis of Goodpasutre syndrome. False positive results may occur due to reactivity against other chains of type IV collagen. If MAFD is negative but there is strong suspicion for disease, renal biopsy may be indicated. A renal biopsy may also be essential in suspected Goodpasture disease with renal involovement, allowing diagnostic confirmation and assesssment of renal prognosis.

• Day Run:
  Sun-Sat (daily)
• Time Reported:
  2-3 days
• Test Type:
  IMMUNOLOGY