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Test Name:
Ganglioside (GM1) IgG and IgM Antibodies

• SBMF No:
  44188
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  GM1
• ABN:
  Required – Not FDA-Approved
• CPT Code:
  83516x2
• LOINC Code:
  51729-2; 51703-7; 29961-0; 29962-8
• Ref Lab Test No:
  0050591
• Test Includes:
  GM1 IgG Antibody
  GM1 IgM Antibody
• Also Known As:
  Anti-GM1 Antibody Panel
  Ganglioside-Monosialic Acid Ab
  GM1 Antibody Panel
• Also See:
  44648 Myelin Associated Glycoprotein IgM Antibody
  44649 Sulfate-3-Glucuronyl Paragloboside IgM Antibody
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Pref Vol:
  0.3 mL
• Min Vol:
  0.1 mL
• Fasting:
  No
• Spec Collect:
  Routine venipuncture
• Spec Process:
  Clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  Room temperature (20-30°C): Unacceptable
  2 weeks refrigerated (2-8°C)
  1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Room temperature sample
  Plasma, CSF, or other body fluid sample
  Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic sample
• Methodology:
  Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
• Clinical Significance:
  Refer to:
  
• Reference Range:
  

  GM1 IgG Antibody
  29 IV or less: Negative
  30-50 IV: Equivocal
  51-100 IV: Positive
  101 IV or greater: Strong Positive

  GM1 IgM Antibody
  29 IV or less: Negative
  30-50 IV: Equivocal
  51-100 IV: Positive
  101 IV or greater: Strong Positive

  Interpretive Data
  Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

• Additional Test Info:
  This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
• Day Run:
  Mon, Wed, Fri
• Time Reported:
  2-5 days
• Test Type:
  IMMUNOLOGY