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Test Name:
Serotonin, Whole Blood
- SBMF No:
44129 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
SEROTONIN- - ABN:
Not required - CPT Code:
84260 - LOINC Code:
2939-7 - Ref Lab Test No:
0080395 - Also Known As:
5-HT, Blood
5-Hydroxytryptamine, Blood - Also See:
44083 Serotonin, Serum - Spec Type:
Whole blood - Spec Container:
Special "ARUP Serotonin Transport Tube" containing ascorbic acid
(Tubes are available through Client Services) - Pref Vol:
3.0 mL - Min Vol:
1.0 mL - Fasting:
No - Patient Prep:
Abstain from medications for 72 hours prior to collection - Spec Collect:
Routine venipuncture
Collect in lavender top (EDTA) tube
Place on ice - Spec Process:
Transfer whole blood into an "ARUP Serotonin Transport Tube"
Mix well and freeze
Specimen must be preserved and frozen within 2 hours of collection - Spec Store Transport:
Frozen - Spec Stability:
After transfer to Serotonin Transport Tube:
Room temperature (20-30°C): Unacceptable
Refrigerated (2-8°C): Unacceptable
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Specimens other than whole blood
Non-frozen sample - Spec Remarks:
CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered - Methodology:
Quantitative High Performance Liquid Chromatography (HPLC) - Clinical Significance:
Refer to:
- Reference Range:
50-200 ng/mL
Note:
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL. - Day Run:
Sun, Wed, Fri - Time Reported:
2-6 days - Test Type:
HORMONE
