South Bend Medical Foundation - Your Community Laboratory

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Test Name:
Fluoxetine and Metabolite, Serum or Plasma

• SBMF No:
  44092
• Performance Lab Name:
  ARUP Laboratories
• Test Mnemonic:
  FLUOXE
• ABN:
  Not required
• CPT Code:
  80299x2
• LOINC Code:
  3644-2; 3868-7
• Ref Lab Test No:
  0090450
• Test Includes:
  Fluoxetine
  Norfluoxetine
• Also Known As:
  Fluoxetine/Norfluoxetine
  Oxactin
  Prozac
  Rapiflux
  Sarafem
  Selfemra
• Spec Type:
  Serum
• Spec Container:
  Red top (serum) tube
• Alt Spec Type:
  Plasma
• Alt Spec Container:
  Lavender top (EDTA), green top (sodium heparin), or gray top (fluoride/oxalate) tube
• Pref Vol:
  2.0 mL
• Min Vol:
  0.8 mL
• Fasting:
  No
• Spec Collect:
  Do not use gel-barrier tubes for specimen collection
  Routine venipuncture
• Spec Process:
  Serum sample tubes, clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum or plasma to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  After separation from cells:
  12 hours room temperature (20-30°C)
  5 days refrigerated (2-8°C)
  1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Methodology:
  High Performance Liquid Chromatography (HPLC)
• Use:
  Therapeutic Drug Monitoring
• Reference Range:
  

  Fluoxetine
  Dose-Related Range: 50-480 ng/mL

  Norfluoxetine
  Dose-Related Range: 50-450 ng/mL

  Interpretive Data:
  Dose-related ranges for fluoxetine/norfluoxetine are based on a 20 to 60 mg dose/day.

• Day Run:
  Mon, Wed, Fri
• Time Reported:
  2-5 days
• Test Type:
  TOX-TDM