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Test Name:
Serotonin, Serum
- SBMF No:
44083 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
SEROT-SER - ABN:
Not required - CPT Code:
84260 - LOINC Code:
27057-9 - Ref Lab Test No:
0080397 - Also Known As:
5-HT, Serum
5-Hydroxytryptamine, Serum - Also See:
44129 Serotonin, Whole Blood - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.3 mL - Fasting:
No - Patient Prep:
Abstain from medications for 72 hours prior to collection - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to serparate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Stability:
After separation from cells:
Room temperature (20-30°C): Unacceptable
24 hours refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Specimens other than serum
Non-frozen sample - Spec Remarks:
CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered
Separate serum from cells within one hour of collection - Methodology:
Quantitative High Performance Liquid Chromatography (HPLC) - Clinical Significance:
Refer to:
- Reference Range:
50-220 ng/mL
Note:
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.In general, EDTA whole blood (as compared to serum) preserved with ascorbic acid will give values most representative of blood concentrations. Most (95 percent) of blood serotonin is found in platelets. Refer to Serotonin, Whole Blood (SBMF test code 44129).
- Day Run:
Sun, Wed, Fri - Time Reported:
2-6 days - Test Type:
CHEMISTRY
