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Test Name:
Neuronal Nuclear IgG Antibody Titer, by IFA, Serum
- SBMF No:
44065 - Performance Lab Name:
ARUP Laboratories - Test Mnemonic:
ANNAGIFA - ABN:
Required – Not FDA-Approved - CPT Code:
86256 - LOINC Code:
44770-6 - Ref Lab Test No:
0050912 - Also Known As:
ANNA IgG Titer - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL
Pediatric Collection: 0.15mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Stability:
After separation from cells:
48 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Severely lipemic, contaminated, heat-inactivated, or hemolyzed sample - Spec Remarks:
Separate serum from cells ASAP - Methodology:
Indirect Fluorescent Antibody (IFA) - Use:
For research purposes
Aid in the diagnosis of paraneoplastic syndromes associated with carcinoma of lung, breast, ovary, thymoma or Hodgkin lymphoma - Clinical Significance:
Refer to:
- Reference Range:
- Neuronal Nuclear IgG Antibody (ANNA) Titer, by IFA, Serum
- Less than 1:10 No antibody detected
Interpretive Data:- A titer of greater than or equal to 1:10 indicates antibody was detected to either ANNA-1 (anti-Hu) or ANNA-2 (anti-Ri). An immunoblot assay should be completed for confirmation of ANNA-1 or ANNA-2.
Note:- Titers of greater than or equal to 1:10 indicate antibody was detected to either ANNA-1 (anti-Hu) or ANNA-2 (anti-Ri) and will be titered to endpoint. This test is used primarily for titering patient sera that have previously been confirmed as positive for either ANNA-1 or ANNA-2 by immunoblot. Only an immunoblot can differentiate between ANNA-1 and ANNA-2.
- Additional Test Info:
This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. - Day Run:
Wed - Time Reported:
2-10 days - Test Type:
IMMUNOLOGY
