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Test Name:
SRP Autoantibodies


  • SBMF No:
    43018
  • Performance Lab Name:
    Quest Diagnostics Nichols Institute
  • Test Mnemonic:
    SRP AUTOAB
  • ABN:
    Not required
  • CPT Code:
    86235
  • LOINC Code:
    19146-0
  • Ref Lab Test No:
    1227
  • Also Known As:
    Signal Recognition Particle Autoantibodies
    Anti-SRP
  • Also See:
    28372 Antinuclear IgG Antibody Screen with Myositis Panel if Indicated
    28340 Jo-1 IgG Antibody
    43207 Myositis AssessR
    28348 Myositis Panel
    28329 SSA (Ro) IgG Antibody
  • Spec Type:
    Serum
  • Spec Container:
    Red top (serum) tube
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.5 mL
  • Fasting:
    No
  • Spec Collect:
    Do not use gel-barrier tubes for specimen collection
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    1 week at room temperature (20-30°C)
    2 weeks refrigerated (2-8°C)
    2 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Remarks:
    Separate serum from cells within 4 hours of collection
  • Methodology:
    Radioimmunoprecipitation Assay (RIPA)
  • Use:
    Polymyositis
  • Clinical Significance:
    Autoantibodies to signal recognition particles (SRP) like mitochondrial, ribosomal, and certain cytoplasmic autoantibodies stain the cytoplasm of HEp-2 cells and can be detected by RIP, EIA and cytoplasmic (non-Jo-1) fluorescence in about 4% of polymyositis/dermatomyositis (PM/DM) patient sera, especially classical adult PM. SRP autoantibodies define a homogeneous group of patients with similar clinical characteristics (typically black females with acute onset of severe polymyositis in the fall together with cardiac involvement and resistance to therapy, including corticosteroids; and mortality at 5 years is 75%). SRP autoantibodies usually are not detected in patients with arthritis (which is common in PM with synthetase autoantibodies), dermatomyositis, pulmonary fibrosis or Raynaud phenomenon.
  • Reference Range:
    Not detected
  • Day Run:
    Tue
  • Time Reported:
    8-15 days
  • Test Type:
    IMMUNOLOGY

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