SBMF Online Payment ▶

test directorySearch Results

Click here to search again.

Test Name:
D-Lactate, Urine


  • SBMF No:
    42288
  • Performance Lab Name:
    Mayo Medical Laboratories
  • Test Mnemonic:
    U DLACTATE
  • ABN:
    Required – Not FDA-Approved
  • CPT Code:
    83605
  • Ref Lab Test No:
    8873
  • Also Known As:
    Lactate (D), Urine
  • Also See:
    42105 D-Lactate, Plasma
    23082 Lactic Acid, Plasma
    44074 Organic Acids, Urine
  • Spec Type:
    Urine, random
  • Spec Container:
    Plastic transport tube with threaded cap
  • Pref Vol:
    2.5 mL
  • Min Vol:
    0.5 mL
  • Spec Collect:
    Routine random or timed urine collection
  • Spec Process:
    Aliquot 2.5 mL and immediately freeze
  • Spec Store Transport:
    Frozen
  • Spec Reject:
    Non-frozen sample
  • Methodology:
    Enzymatic
  • Use:
    Diagnosing D-lactate acidosis, especially in patients with jejunoileal bypass and short-bowel syndrome.
  • Clinical Significance:

    D-lactate is produced from carbohydrates not absorbed in the small intestine by bacteria residing in the colon. When large amounts are absorbed it can cause metabolic acidosis, altered mental status (from drowsiness to coma) and a variety of other neurologic symptoms, in particular dysarthria and ataxia. Although a temporal relationship has been described between elevations of plasma and urine D-lactate and the accompanying encephalopathy, the mechanism of neurologic manifestations has not been elucidated.

    D-lactic acidoses is typically observed in patients with short-bowel syndrome and following jejunoileal bypass resulting in carbohydrate malabsorption. In addition, healthy children presenting with gastroenteritis may also develop the critical presentation of D-lactic acidosis.

    Measured concentrations are diagnostic, but It is important to realize that lactic acid determinations in blood will not reveal abnormalities because routine lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested. Because D-lactate is readily excreted, urine is the preferred specimen for D-lactate determinations.

  • Reference Range:

    0.0-0.25 mmol/L

    Interpretation
    Increased levels are diagnostic

    Clinical Reference
    1. Dahlquist NR, Perrault J, Callaway CW, Jones JD: D-Lactic acidosis and encephalopathy after jejunoileostomy: response to overfeeding and to fasting in humans. Mayo Clin Proc 1984;59:141-145

    2. Uribarri J, Oh MS, Carroll HJ: D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms. Medicine 1998;77:73-82

    3. Hingorani AD, Chan NN: D-lactate encephalopathy. Lancet 2001; Nov 24;358(9295):1814

  • Additional Test Info:
    This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared or approved by the U.S. Food and Drug Administration.
  • Day Run:
    Varies
    NOTE: This test experiences significant delays due to inconsistent reagent availability from the manufacturer
  • Time Reported:
    Within 2 months
  • Test Type:
    CHEMISTRY

Home > Test Directory > Search Results

Test Directory