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Test Name:
Carbohydrate Deficient Transferrin, Adult, Serum
- SBMF No:
42276 - Performance Lab Name:
Mayo Medical Laboratories - Test Mnemonic:
CDT AD - ABN:
Required – Not FDA-Approved - CPT Code:
82373 - LOINC Code:
19146-0 - Ref Lab Test No:
82425 - Also Known As:
CDT (Carbohydrate Deficient Transferrin)
Transferrin Isoforms - Also See:
42274 Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation, Serum - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
0.1 mL - Min Vol:
0.05 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Remarks:
Patient's age is required on request form for processing
Reason for referral is required if patient is less than 21 years old - Methodology:
Affinity Chromatography/Mass Spectrometry (MS) - Use:
An indicator of chronic alcohol abuse
NOTE: This test is for evaluation of alcohol abuse. If the ordering physician is looking for congenital disorders of glycosylation, please order #42274 "Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation, Serum." - Clinical Significance:
Chronic alcoholism causes a transient change in the glycosylation pattern of transferrin where the relative amounts of disialo- and asialotransferrin (carbohydrate deficient transferrin [CDT]) are increased over the amount of normally glycosylated tetrasialotransferrin. This recognition led to the use of CDT in serum as marker for chronic alcohol abuse. CDT typically normalizes within several weeks of abstinence of alcohol use. However, it is important to recognize that there are other causes of abnormal CDT levels, which include congenital disorders of glycosylation (CDG) and other genetic and nongenetic causes of acute or chronic liver disease.
CDT testing alone is not recommended for general screening for alcoholism; however, when combined with other methods (ie, gamma-glutamyltransferase [GGT], mean corpuscular volume [MCV], patient self-reporting) clinicians can expect to identify 90% or more of heavily drinking patients.
- Reference Range:
Carbohydrate Deficient Transferrin, Adult, Serum
< or = 0.10
0.11 - 0.12 (indeterminate)Interpretation:
Patients with chronic alcoholism may develop abnormally glycosylated transferrin isoforms (ie, CDT > 0.12). CDT results from 0.11 to 0.12 are considered indeterminate.Patients with liver disease due to genetic or nongenetic causes may also have abnormal results.
- Additional Test Info:
This assay has not been fully validated for the investigation of alcoholism.
CDT testing alone is not recommended for general screening for alcoholism.
The abnormal transferrin isoform pattern in patients with chronic alcoholism is similar to that observed in CDGS. However, unlike most patients with CDG, the relative amount of mono-glycosylated transferrin is much lower. Other conditions such as hereditary fructose intolerance, galactosemia, and liver disease may result in increased levels of CDT.
This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared or approved by the U.S. Food and Drug Administration.
Reference:
"Carbohydrate Deficient Transferrin, Adult, Serum." 2011 Online Test Catalog, Mayo Medical Laboratories, 2011. Web. 30 October 2011 <http://www.mayomedicallaboratories.com/test-catalog/Overview/82425> - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
4-7 days - Test Type:
CHEMISTRY
