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Test Name:
Neutrophil Antibodies, by IFA


  • SBMF No:
    42250
  • Performance Lab Name:
    Mayo Medical Laboratories
  • Test Mnemonic:
    LAGG/TT
  • ABN:
    Required – Not FDA-Approved
  • CPT Code:
    86021
  • LOINC Code:
    19146-0
  • Ref Lab Test No:
    LAGGT | 8976
  • Also Known As:
    Anti-Leukocyte Antibodies
    Anti-Granulocyte Antibodies
    Anti-Neutrophil Antibodies
    Granulocyte Antibodies
    Granulocyte Binding IgG
    Leukoagglutinin
  • Also See:
    44427 Neutrophil-Associated Antibodies, by Flow Cytometry
  • Spec Type:
    Serum
  • Spec Container:
    Red top (serum) tube
  • Pref Vol:
    1.5 mL
  • Min Vol:
    0.3 mL
  • Fasting:
    No
  • Spec Collect:
    Do not use gel-barrier tubes for specimen collection
    Routine venipuncture
    Note: Only pretransfusion reaction specimen is acceptable
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Reject:
    Specimen collected in gel-barrier tube
    Specimen collected after transfusion reaction
  • Methodology:
    Indirect Immunofluorescence Assay (IFA)
  • Use:
    The work-up of individuals having febrile, nonhemolytic transfusion reactions
    The detection of individuals with autoimmune neutropenia
  • Clinical Significance:
    Granulocyte antibodies are induced by pregnancy or prior transfusion and are associated with febrile, nonhemolytic transfusion reactions. Patients who have been immunized by previous transfusions, pregnancies, or allografts frequently experience febrile, nonhemolytic transfusion reactions which must be distinguished from hemolysis before further transfusions can be safely administered. Granulocyte antibodies may also be present in autoimmune neutropenia.
  • Reference Range:

    Reference values not applicable

    Interpretation:
    A positive result in an individual being worked up for a febrile transfusion reaction indicates the need for leukocyte-poor (filtered) red blood cells.

    This test cannot distinguish between allo- and autoantibodies

    Cautions:
    Not useful for diagnosis of neutropenia caused by marrow suppression by drugs or tumors

    Reference:
    "Granulocyte Antibodies, Serum." 2011 Online Test Catalog, Mayo Medical Laboratories, 2011. Web. 18 November 2011 <http://www.mayomedicallaboratories.com/test-catalog/Overview/8976>

  • Additional Test Info:
    This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
  • Day Run:
    Mon, Wed, Fri
  • Time Run:
    7:30 am - 5:00 pm
  • Time Reported:
    8-15 days
  • Test Type:
    IMMUNOLOGY

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