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Test Name:
Estrogen/Progesterone Receptor Assay, Paraffin Block
- SBMF No:
38551 - Performance Lab Name:
Anatomic Pathology - Test Mnemonic:
PRFN ERPR - ABN:
Not required - CPT Code:
88360x2 - Test Includes:
Immunohistochemistry
Pathology interpretation - Also Known As:
ER/PR - Spec Type:
Tissue section - Spec Container:
Formalin-fixed paraffin-embedded (FFPE) tumor tissue - Fasting:
No - Spec Collect:
The appropriate specimen for testing is a properly fixed and processed tissue specimen embedded in a paraffin block
Neutral buffered formalin is the preferred fixative and tissues should be sectioned and fixed in neutral buffered formalin as soon as possible after surgery for best immunohistochemical staining properties
In selecting the paraffin block, submit the largest area of tumor available that show the least degeneration or necrosis and the least fibrous stroma
Preservation of nuclear detail can help assess quality of fixation - Spec Store Transport:
Room temperature
Avoid excessive heat (greater than 55°C) during transportation of specimen - Spec Stability:
Room temperature (20-30°C), indefinitely - Methodology:
Immunohistochemistry - Use:
A useful biochemical parameter in deciding which patients with breast cancer should be treated by endocrine therapy such as androgens, tamoxifen, or adrenalectomy - Clinical Significance:
The hormone receptor assays lend predictive value to the patient's response to endocrine therapy. Evidence exists that the incidence of response is enhanced when progesterone receptor is also present. Meningiomas frequently contain progesterone receptors. Such assays are sometimes useful for female patients with metastatic adenocarcinoma of unknown primary site. - Reference Range:
Estrogen and progesterone receptors by immunohistochemistry are reported as: positive (with 15% to greater than 90% nuclear positivity), weakly positive (with 5% to 10% nuclear positivity), and negative (with 0% to less than 5%) nuclear positivity. - Test Type:
AP
