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Test Name:
HE4, Ovarian Cancer Monitoring


  • SBMF No:
    33051
  • Performance Lab Name:
    Quest Diagnostics Nichols Institute
  • Test Mnemonic:
    HE4
  • ABN:
    Not required
  • CPT Code:
    86305
  • LOINC Code:
    19146-0
  • Ref Lab Test No:
    2040
  • Also Known As:
    Human Epididymis Protein 4 (HE4)
  • Spec Type:
    Serum
  • Spec Container:
    Red top (serum) or gold top (SST) tube
  • Pref Vol:
    0.5 mL
  • Min Vol:
    0.1 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
  • Spec Store Transport:
    Room temperature
  • Spec Stability:
    5 days room temperature (20-30°C)
    1 week refrigerated (2-8°C)
    4 weeks frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Sample with heavy particulate matter
    Hemolyzed, lipemic, or icteric sample
  • Spec Remarks:
    Separate serum from cells ASAP
  • Methodology:
    Enzyme Immunoassay (EIA)
  • Clinical Significance:
    The HE4 EIA assay is an enzyme immunoassay for the quantitative determination of human HE4 antigen in serum. HE4 is a biomarker for ovarian cancer.
  • Reference Range:
    < 151 pM
  • Day Run:
    Tue, Fri
  • Time Reported:
    Next day
    This is a sendout test. Please note that turnaround time is defined as the anticipated time from set up day to results release.
  • Test Type:
    TUMOR MARKER