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Test Name:
C4d Fragment, EIA
- SBMF No:
33050 - Performance Lab Name:
Quest Diagnostics Nichols Institute - Test Mnemonic:
C4D - ABN:
Required – Not FDA-Approved - CPT Code:
83520 - LOINC Code:
19146-0 - Ref Lab Test No:
4943N - Spec Type:
Plasma - Spec Container:
Lavender top (EDTA) tube - Pref Vol:
1.0 mL - Min Vol:
0.2 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Promptly centrifuge 15 minutes
Immediately transfer plasma to separate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Stability:
Room temperature (20-20°C): Unacceptable
4 hours refrigerated (2-8°C)
2 weeks frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Thawed sample - Methodology:
Enzyme Immunoassay (EIA) - Clinical Significance:
C4d is a stable activation product of C4 cleavage. C4d is useful in determining classical pathway activation. Concentrations of C4d are increased in patients with immune complex diseases such as systemic lupus erythematosus (SLE) and immune complex-induced vasculitis. - Reference Range:
- C4d Fragment, EIA
- 0.9-8.0 mcg/mL
- Interpretive Data:
- C4d is a split product of C4b. It is elevated in sera or plasma of patients with immune complex disease or in patients with classical complement pathway activation (such as hereditary angioedema).
- Additional Test Info:
This test is performed using a kit that has not been approved or cleared by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. This test should not be used for diagnosis without confirmation by other medically established means. - Day Run:
Wed - Time Reported:
Same day
This is a sendout test. Please note that turnaround time is defined as the anticipated time from set up day to results release. - Test Type:
IMMUNOLOGY
