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Test Name:
Vancomycin, Random or Non-Specified
- SBMF No:
31045 - Performance Lab Name:
Automated Lab - Test Mnemonic:
VANCO - ABN:
Not required - CPT Code:
80202 - LOINC Code:
13587-1 - Also Known As:
Aminoglycoside
Vancocin® - Also See:
29145 Vancomycin, Trough
29155 Vancomycin, Peak - Spec Type:
Serum - Spec Container:
Red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (potassium EDTA) tube - Pref Vol:
1.0 mL - Min Vol:
0.3 mL - Fasting:
No - Spec Collect:
Do not use gel-barrier tubes for specimen collection
Routine venipuncture
Collect "peak" 2 hours after end of a 60 minute infusion of vancomycin
Collect "trough" just before next dose - Spec Process:
Refrigerate tube of blood and transport refrigerated on day collected
If specimen not sent to SBMF on day collected:
• Serum tube samples, clot 30 minutes
• All tubes, promptly centrifuge 15 minutes
• Immediately transfer serum or plasma to separate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Stability:
3 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Heparinized sample - Methodology:
Enzyme Immunoassay (EIA) - Use:
Used in monitoring therapeutic vancomycin level in blood - Clinical Significance:
Vancomycin is a complex glycopeptides antibiotic, which has been used to treat penicillinase-producing staphylococci. It is the drug of choice for the treatment of methiciliin and related beta lactam antibiotic resistant Staphylococcus aureus as well as for the treatment of serious gram-positive infections where allergies to pencillin or cephalosporin play a role. Vancomycin is also used in the treatment of antibiotic-induced enterocolitis associated with Clostridium difficile and streptococcal or enterococcal endocarditis, the latter in conjunction with an aminoglocyside, when penicillin or ampicillin is not an option. - Reference Range:
Vancomycin Trough Level: Minimum serum concentration for infection control is 10 µg/mL. A target therapeutic range of 15-20 µg/mL for a trough level is recommended for complicated infections. There are limited data suggesting a direct causal relationship between toxicity and serum concentrations. - Critical High Value:
≥ 80.1 µg/mL - Additional Test Info:
Vancomycin Peak Level: No longer routinely recommended for therapeutic monitoring. - Day Run:
Sun-Sat (daily) - Time Run:
As received - Time Reported:
4 hours - Test Type:
TOX-TDM
