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Test Name:
IgE, Quantitative, Serum


  • SBMF No:
    30099
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    IGE
  • ABN:
    Not required
  • CPT Code:
    82785
  • LOINC Code:
    19113-0
  • Also Known As:
    Immunoglobulin E
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Alt Spec Type:
    Plasma
  • Alt Spec Container:
    Green top (heparin) or Lavender top (EDTA) tube
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.3 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
    Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    24 hours room temperature (20-30°C)
    1 week refrigerated (2-8°C)
    Greater than 1 week, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Methodology:
    ImmunoCAP™ Fluorescent Enzyme Immunoassay (FEIA)
  • Use:
    Diagnose and manage patients with atopic disease such as asthma, hay fever, eczema, and patients with respiratory allergies or parasitic infections
  • Clinical Significance:
    Immunoglobulin E (IgE) is a class of immunoglobulins important in the mediation of allergic responses. IgE is synthesized primarily within plasma cells found in the mucosa of the respiratory and intestinal tracts and is secreted into the blood. The mechanism of action of the allergic response involves the binding of IgE through its Fc portion to cell surface receptors of mast cells and basophils. After exposure to specific allergens recognized by IgE, the cells release vasoactive amines causing Type I hypersensitivity reactions. IgE levels may be increased in not only allergic disease, but also parasitic infections and bronchopulmonary aspergillosis.
  • Reference Range:
    IgE, Quantitative
    Geometric Mean 1 SD 2 SD 
     kU/L kU/L kU/L 
    ___________   _______  _______  _______ 
    Newborn0.5  1  2  
    1 year3  15  83  
    2 years6  29  133  
    3 years12  35  101  
    4 years7  33  144  
    5 years–Adult20  75  260  

    For any age group, the reference range is up to the 1 SD value. Levels less than the geometric mean indicate atopic genesis not probable. Levels greater than the 2 SD value indicate atopic genesis highly probable. Levels between 1 and 2 SD are equivocal and in children may predict future onsit of allergic disease.

  • Day Run:
    Mon-Fri
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    IMMUNOLOGY

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