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Test Name:
Follicle Stimulating Hormone, Serum
- SBMF No:
30093 - Performance Lab Name:
Automated Lab - Test Mnemonic:
FSH - ABN:
Not required - CPT Code:
83001 - LOINC Code:
15067-2 - Also Known As:
FSH, Serum - Also See:
29093 Follicle Stimulating Hormone, 24-Hour Urine - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (EDTA) tube or green top (lithium heparin) tube - Pref Vol:
1.6 mL - Min Vol:
0.8 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
2 weeks refrigerated (2-8°C )
6 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Heat-inactivated sample - Spec Remarks:
Preferred specimen is primary serum sample contained in properly centrifuged gel barrier tube (not necessary to transfer serum to separate tube) - Methodology:
Electrochemiluminescent Immunoassay (ECLIA) - Use:
Excessive FSH in hypogonadism indicates gonadal insufficiency. Pituitary function test, useful to distinguish primary gonadal failure from secondary (hypothalamic/pituitary) causes of menstrual disturbances and amenorrhea. Inadequate corpora lutea are related to low FSH levels. Useful in defining menstrual cycle phases in infertility evaluation of women and testicular dysfunction in men. - Clinical Significance:
FSH (follicle stimulating hormone), like LH (luteinizing hormone), belongs to the gonadotropin family, FSH and LH synergistically regulate and stimulate the growth and function of the gonads (ovaries and testes). Similarly to LH, TSH and hCG, FSH is a glycoprotein consisting of two subunits (a- and b-chains). Its molecular weight is approximately 32,000 D. In women, the gonadotropins act within the hypothalamus-pituitary-ovary regulating circuit to control the menstrual cycle.FSH and LH are released in pulses from the gonadotropic cells of the anterior pituitary. Steroid hormones via negative feedback to the hypothalamus control the levels of the circulating hormones. In the ovaries FSH, together with LH, stimulates the growth and maturation of the follicle and hence also the biosynthesis of estrogens in the follicles. The FSH level shows a peak at mid-cycle, although this is less marked than with LH. Due to changes in ovarian function and reduced estrogen secretion, high FSH concentrations occur during menopause.In men, FSH serves to induce spermatogonium development. The determination of FSH is utilized in the elucidation of functional disorders within the hypothalamus-pituitary-gonad system. The determination of FSH together with LH is indicated for the following: congenital diseases with chromosome aberrations, amenorrhea (causes), polycystic ovaries (PCO) and menopausal syndrome. Depressed gonadotropin levels in men occur in azoospermia. - Reference Range:
Male: - less than 60:years - 0.8-13.9 mIU/mL - 60-70 years: 0.9-15.0 mIU/mL - greater than 70 years: 2.8-55.5 mIU/mL
Female: - Follicular: 1.1-9.6 mIU/mL - Ovulatory: 2.3-20.9 mIU/mL - Luteal: 0.8-7.5 mIU/mL - Postmenopausal: 34.4-95.8 mIU/mL - Day Run:
Sun-Sat (daily) - Time Run:
As received - Time Reported:
4 hours - Test Type:
HORMONE
