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Test Name:
Gastrin
- SBMF No:
30028 - Performance Lab Name:
Immunochemistry - Test Mnemonic:
GASTRIN - ABN:
Not required - CPT Code:
82941 - LOINC Code:
2333-3 - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
2.0 mL - Min Vol:
0.5 mL - Fasting:
Yes - Patient Prep:
Patient should fast at least 12 hours if testing for basal gastrin level - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube and freeze - Spec Store Transport:
Frozen - Spec Stability:
4 hours refrigerated (2-8°C)
Greater than 4 hours, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Non-frozen (greater than 4 hours), lipemic, icteric or severely hemolyzed or sample - Methodology:
Chemiluminescent Immunoassay (CLIA) - Use:
Establish a diagnosis of Zollinger-Ellison tumor (gastrinoma) and other disorders with gastric acid hypersecretion - Clinical Significance:
Gastrin is a major gastrointestinal hormone. It serves to stimulate gastric acid secretion and exists in a number of molecular forms, differing from on another in the length of the polypeptide backbone and in derivatizations of individual amino acids. The three principal forms, G-17, G-34 and G-14, are named for the number of amino acids, which they contain.
Immunoassays for gastrin play an essential role in the identification of Zollinger-Ellison tumors (gastrinomas). These tumors are typically, but not invariably, associated with elevated gastrin levels, gastric acid hypersecretion and peptic ulcer disease.
In fasting subjects, gastrin normally circulates at levels of less than 100 pg/mL with some day to day variability. Fasting gastrin levels in patients with Zollinger-Ellison syndrome are typically very high, well above the reference range for healthy individuals.
Elevated values are also encountered in other conditions. Where gastric acid secretion is impaired, for example in pernicious anemia, gastrin levels are characteristically (and appropriately) increased. Hypergastrinemia and hypersecretion of gastric acid are also encountered in the absence of pancreatic or duodenal tumors. Thus, hypergastrinemia without gastrinoma may be found in pyloric obstruction with antrum distension, after vagotomy, in the “retained antrum” syndrome, and in some patients with ordinary peptic ulcer disease. - Reference Range:
13–115 pg/mL - Day Run:
Wed - Time Run:
8:00 am - Time Reported:
3:30 pm - Test Type:
HORMONE
