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Test Name:
Thyroid Stimulating Hormone, Sensitive
- SBMF No:
30017 - Performance Lab Name:
Automated Lab - Test Mnemonic:
TSH - ABN:
May be required – Medical Necessity - CPT Code:
84443 - LOINC Code:
11580-8 - Also Known As:
High Sensitivity-Thyroid Stimulating Hormone (HS-TSH)
Sensitive TSH
S-TSH
Thyrotropin
TSH, 3rd Generation - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (EDTA) tube or green top (lithium heparin) tube - Pref Vol:
1.5 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
1 week refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Remarks:
Preferred specimen is primary serum sample contained in properly centrifuged gel barrier tube (not necessary to transfer serum to separate tube) - Methodology:
Chemiluminescent Immunoassay (CLIA) - Use:
TSH serves as the initial test in thyroid diagnostics - Clinical Significance:
Thyroid-stimulating hormone (TSH, thyrotropin) is a glycoprotein having a molecular weight of approximately. 30,000 daltons and consisting of two subunits. The beta-subunit carries the TSH-specific immunological and biological information, whereas the alpha-chain carries species-specific information and has an identical amino acid sequence to the alpha-chains of LH, FSH and hCG.TSH is formed in specific basophil cells of the anterior pituitary and is subject to a circardian secretion sequence. The hypophyseal release of TSH (thyrotropic hormone) is the central regulating mechanism for the biological action of thyroid hormones. TSH has a stimulating action in all stages of thyroid hormone formation and secretion; it also has a proliferative effect.The determination of TSH serves as the initial test in thyroid diagnostics. Even very slight changes in the concentrations of the free thyroid hormones bring about much greater opposite changes in the TSH level. Accordingly, TSH is a very sensitive and specific parameter for assessing thyroid function and is particularly suitable for early detection or exclusion of disorders in the central regulating circuit between the hypothalamus, pituitary and thyroid. - Reference Range:
0.27-4.20 µIU/mL
Interpretive Data:
Treatment of adult patients with a TSH level between 3.5-10.0 µIU/mL should be patient specific and based on clinical symptoms and cardiovascular risk factors. TSH below 2.5 µIU/mL is optimal for pregnancy. - Day Run:
Sun-Sat (daily) - Time Run:
As received - Time Reported:
4 hours - Test Type:
HORMONE
