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Test Name:
C-Reactive Protein, High Sensitivity

• SBMF No:
  29227
• Performance Lab Name:
  Automated Lab
• Test Mnemonic:
  CRP-HS
• ABN:
  May be required – Medical Necessity
• CPT Code:
  86141
• LOINC Code:
  30522-7
• Also Known As:
  Cardiac CRP
  Cardio CRP
  CRP, Cardiac
  CRP, High Sensitivity
  CRP, Sensitive
  High Sensitivity CRP
  hs-CRP
  Sensitive CRP
• Also See:
  28228 C-Reactive Protein, Quantitative
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Alt Spec Type:
  Plasma
• Alt Spec Container:
  Lavender top (EDTA) or green top (heparin) top tube
• Pref Vol:
  1.0 mL
• Min Vol:
  0.3 mL
• Fasting:
  Yes
• Patient Prep:
  Fasting at least 12 hours
• Spec Collect:
  Routine venipuncture
• Spec Process:
  Serum sample tubes, clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum or plasma to separate plastic tube
  Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  2 months refrigerated (2-8°C)
  3 years frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Methodology:
  Immunometric
• Use:
  Used as a risk assessment of cardiovascular conditions
• Clinical Significance:
  C-reactive protein (CRP) is one of the most sensitive acute-phase reactants. Historically, CRP has been used to assess a variety of inflammatory conditions. With the recognition that atherosclerosis is an inflammatory process, hs-CRP has been used as an independent risk indicator for developing cardiovascular conditions. Data from prospective studies suggested that the men in the highest CRP quartile had 2 to 4 times the risk of developing myocardial infarction, ischemic stroke, and severe peripheral artery disease compared to the men in the lowest quartile.High sensitivity C-reactive protein assay can accurately measure CRP in the reference range level, 0 to 0.8 mg/dL. This test is to be used in assessment of risk of developing cardiovascular disease or ischemic events in individuals who do not have manifest disease at present. More aggressive treatment strategies may be pursued in patients with basal hs-CRP at highest quartile of reference range. Since CRP is an acute phase reactant, basal hs-CRP should be determined 2 to 3 weeks after any inflammatory conditions.
• Reference Range:
  

  Based on the recommendation from AHA/CDC Scientific Statement published in 2003, the interpretation of high sensitivity CRP(hsCRP) results is modified to the following:

  hsCRP (mg/L)        -------------- < 1.0 mg/L 1.0 - 3.0 mg/L >3.0 mg/L

  Relative Risk of developing cardiovascular disease. ---------------------------           Low           Average           High

  If the hsCRP is >10.0 mg/L, the test should be repeated and the patient examined for sources of inflammation. Patients with persistent, unexplained elevations of hsCRP >10.0 mg/L after repeated testing should be evaluated for noncardiovascular etiologies.

• Additional Test Info:
  C-reactive protein (CRP) is described in the literature as an acute phase protein that is involved in the activation of complement, acceleration of phagocytosis, and detoxification of substances released from damaged tissue. CRP is one of the most sensitive indicators of inflammation.In response to an inflammatory stimulus, a rise in CRP may be detected within six hours. CRP is a sensitive, non-specific indicator of acute phase reactants. The level of CRP in serum is elevated in patients with arthritis or liver disease such as hepatitis A, hepatitis B, or biliary cirrhosis, and after severe infections such as septic shock.
• Day Run:
  Sat-Sun (daily)
• Time Run:
  As received
• Time Reported:
  4 hours
• Test Type:
  HEMATOLOGY